Mosaiques organized an international meeting on collagen and fibrosis in Toulouse in the context of the DisCo-I project (https://www.disco-1.eu/). Worldwide leading scientists, among others, Prof. Hans-Jochen Anders, Prof. Lucas Van Aelst, Prof. Anne-Dominique Lajoix, and Prof. Angel Argiles, gathered to discuss approaches towards early detection of fibrosis and prevention or even reversing this pathological development, that is the main cause for most chronic diseases (cardiovascular disease, kidney disease, liver disease, etc.). A major outcome of the meeting was the clear demonstration that fibrosis can be detected early and possible ways of therapeutic intervention, and molecular mechanisms can be unraveled using omics approaches.