Nov. 2022
The effect of the sodium–glucose cotransporter 2 (SGLT-2) inhibitor Dapagliflozin was evaluated on the kidney-risk urinary proteomic classifier (CKD273) in persons with type 2 diabetes (T2D) and albuminuria.
Nov. 2022
The delayed diagnosis of acute kidney injury (AKI) episodes and the lack of specificity of current single AKI biomarkers hamper its management. Urinary peptidome analysis may help to identify early molecular changes in AKI and grasp its complexity to identify potential targetable molecular pathways.
Oct. 2022
Non-invasive urine-based biomarkers can potentially improve current diagnostic and monitoring protocols for bladder cancer (BC). Here we assess the performance of earlier published biomarker panels for BC detection (BC-116) and monitoring of recurrence (BC-106) in combination with cytology, in two prospectively collected patient cohorts.
Oct. 2022
The SARS-CoV-2 pandemic is a worldwide challenge. The CRIT-CoV-U pilot study generated a urinary proteomic biomarker consisting of 50 peptides (COV50), which predicted death and disease progression from SARS-CoV-2. After the interim analysis presented for the German Government, here, we aimed to analyse the full dataset to consolidate the findings and propose potential clinical applications of this biomarker.
Sept. 2022
Prostate cancer (PC) is a leading cause of morbidity and mortality among men worldwide. One major issue in PCa research is to accurately distinguish between indolent and clinically significant (csPCa) to reduce overdiagnosis and overtreatment.
A new study was published, dealing with the validation of diagnostic nomograms (DN) based on proteomic urinary biomarkers to detect clinically significant prostate cancer.
Oct. 2021
By Marilynn Larkin
SOURCE: https://www.mdalert.com/news/article/urinary-peptidomic-profile-predicts...
NEW YORK (Reuters Health) - Researchers have produced and validated a urinary peptidomic profile (UPP) biomarker that distinguishes healthy from unhealthy aging based on fibrosis and extracellular matrix (ECM) remodeling in patients with chronic diseases.
A consortium of researchers belonging to the Research Institute Alliance for the Promotion of Preventive Medicine (Mechelen, Belgium), Mosaiques-Diagnostics (Hannover, Germany), Hospital, St. Georg (Leipzig, Germany), and the Universities of Hasselt and Leuven in Belgium and other European Research Institutes published today an article in The Lancet Healthy Longevity that shows data underpinning the groundbreaking idea that analysis of a small urine sample provides information on a person’s biological age and the probability of that a person will age healthy.
