Scientific Articles Oncology


Frantzi M, Latosinska A, Belczacka I, Mischak H.

Urinary proteomic biomarkers in oncology: ready for implementation?

Expert Rev Proteomics. 2018 Nov 9. doi: 10.1080/14789450.2018.1547193. [Epub ahead of print]

PMID: 30412678

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Huang QF, Van Keer J, Zhang ZY, Trenson S, Nkuipou-Kenfack E, Van Aelst LNL, Yang WY, Thijs L, Wei FF, Ciarka A, Vanhaecke J, Janssens S, Van Cleemput J, Mischak H, Staessen JA.

Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients.

PLoS One. 2018 Sep 24;13(9):e0204439. doi: 10.1371/journal.pone.0204439. ECollection 2018.

PMID: 30248148

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Belczacka I, Latosinska A, Metzger J, Marx D, Vlahou A, Mischak H, Frantzi M.

Proteomics biomarkers for solid tumors: Current status and future prospects.

Mass Spectrom Rev. 2018 Jun 11. doi: 10.1002/mas.21572. [Epub ahead of print] Review.

PMID: 29889308

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Belczacka I, Latosinska A, Siwy J, Metzger J, Merseburger AS, Mischak H, Vlahou A, Frantzi M, Jankowski V.

Urinary CE-MS peptide marker pattern for detection of solid tumors.

Sci Rep. 2018 Mar 27;8(1):5227. doi: 10.1038/s41598-018-23585-y. [Epub ahead of print]

PMID: 29588543

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Latosinska A, Mokou M, Makridakis M, Mullen W, Zoidakis J, Lygirou V, Frantzi M, Katafigiotis I, Stravodimos K, Hupe MC, Dobrzynski M, Kolch W, Merseburger AS, Mischak H, Roubelakis MG, Vlahou A.
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.
Oncotarget. 2017 Apr 20;8(41):69435-69455. doi: 10.18632/oncotarget.17279. eCollection 2017 Sep 19.

PMID: 29050215

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Latosinska A, Frantzi M, Vlahou A, Merseburger AS, Mischak H.
Clinical Proteomics for Precision Medicine: The Bladder Cancer Case.
Proteomics Clin Appl. 2017 Oct 5. doi: 10.1002/prca.201700074. [Epub ahead of print] Review.

PMID: 28980455

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Voigtländer T, Metzger J, Schönemeier B, Jäger M, Mischak H, Manns MP, Lankisch TO.
A combined bile and urine proteomic test for cholangiocarcinoma diagnosis in patients with biliary strictures of unknown origin.
United European Gastroenterol J. 2017 Aug;5(5):668-676. doi: 10.1177/2050640616687836. Epub 2017 Jan 11.

PMID: 28815030

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Latosinska A, Makridakis M, Frantzi M, Borràs DM, Janssen B, Mullen W, Zoidakis J, Merseburger AS, Jankowski V, Mischak H, Vlahou A.
Integrative analysis of extracellular and intracellular bladder cancer cell line proteome with transcriptome: improving coverage and validity of -omics findings.
Sci Rep. 2016 May 11;6:25619. doi: 10.1038/srep25619.

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Bhat A, Mokou M, Zoidakis J, Jankowski V, Vlahou A, Mischak H.
BcCluster: A Bladder Cancer Database at the Molecular Level.
Bladder Cancer. 2016 Jan 7;2(1):65-76.

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Frantzi M, Van Kessel KE, Zwarthoff EC, Marquez M, Rava M, Malats N, Merseburger AS, Katafigiotis I, Stravodimos K, Mullen W, Zoidakis J, Makridakis M, Pejchinovski M, Critselis E, Lichtinghagen R, Brand K, Dakna M, Roubelakis MG, Theodorescu D, Vlahou A, Mischak H, Anagnou NP.
Development and validation of urine-based peptide biomarker panels for detecting bladder cancer in a multi-center study.
Clin Cancer Res. 2016 Mar 29. pii: clincanres.2715.2015. [Epub ahead of print]

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Latosinska A, Vougas K, Makridakis M, Klein J, Mullen W, Abbas M, Stravodimos K, Katafigiotis I, Merseburger AS, Zoidakis J, Mischak H, Vlahou A, Jankowski V.
Recent progress in urinary proteome analysis for prostate cancer diagnosis and management.
PLoS One. 2015 Sep 2;10(9):e0137048. doi: 10.1371/journal.pone.0137048. eCollection 2015.

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Frantzi M, Latosinska A, Flühe L, Hupe MC, Critselis E, Kramer MW, Merseburger AS, Mischak H, Vlahou A.
Developing proteomic biomarkers for bladder cancer: towards clinical application.
Nat Rev Urol. 2015 Jun;12(6):317-330. doi: 10.1038/nrurol.2015.100. Epub 2015 May 26. Review.

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Bhat A, Dakna M, Mischak H.
Integrating proteomics profiling data sets: a network perspective.
Methods Mol Biol. 2015;1243:237-53. doi: 10.1007/978-1-4939-1872-0_14.

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Neuhaus J, Schiffer E, Siwy J, Mannello F, Horn LC, Stolzenburg JU
Proteome-based diagnostic and prognostic biomarkers of prostate cancer.
Urologe A. 2013 Sep;52(9):1251-5. doi: 10.1007/s00120-013-3308-0.

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Latosinska A, Frantzi M, Vlahou A, Mischak H
Clinical applications of capillary electrophoresis coupled to mass spectrometry in biomarker discovery: Focus on Bladder Cancer.
Proteomics Clin Appl. 2013 Aug 23. doi: 10.1002/prca.201300038. [Epub ahead of print]

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Frantzi M, Zoidakis J, Papadopoulos T, Zurbig P, Katafigiotis I, Stravodimos K, Lazaris A, Giannopoulou I, Ploumidis A, Mischak H, Mullen WB, Vlahou A.
IMAC fractionation in combination to LC/MS reveals H2B and NIF-1 peptides as potential bladder cancer biomarkers.
J Proteome Res. 2013 Aug 7. [Epub ahead of print]

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Neuhaus J, Schiffer E, Wilcke P, Bauer HW, Leung H, Siwy J, Ulrici W, Paasch U, Horn LC, Stolzenburg J
Seminal Plasma as a Source of Prostate Cancer Peptide Biomarker Candidates for Detection of Indolent and Advanced Disease
PLoS ONE 8(6): e67514. doi:10.1371/journal.pone.0067514

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Metzger J, Negm AA, Plentz RR, Weismüller TJ, Wedemeyer J, Karlsen TH, Dakna M, Mullen W, Mischak H, Manns MP, Lankisch TO
Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders
Gut. 2013 Jan;62(1):122-30. doi: 10.1136/gutjnl-2012-302047. Epub 2012 May 12.

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Schiffer E, Bick C, Grizelj B, Pietzker S, Schöfer W
Urinary proteome analysis for prostate cancer diagnosis: Cost-effective application in routine clinical practice in Germany
Int J Urol. 2012 Feb;19(2):118-25. doi: 10.1111/j.1442-2042.2011.02901.x. Epub 2011 Nov 22.
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Schiffer E
Urinary proteomics: ready for prime time in urological cancer diagnostics?
Personalized Medicine 2011, Jan;8 (1): 81-94
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Lankisch TO, Metzger J, Negm AA, Voßkuhl K, Schiffer E, Siwy J, Weismüller TJ, Andrea S. Schneider AS, Thedieck K, Baumeister R, Zuerbig P, Weissinger EM, Manns MP, Mischak H, Wedemeyer J
Bile proteomic profiles differentiates cholangiocarcinoma from primary sclerosing cholangitis and choledocholithiasis
Hepatology. 2011 Mar;53(3):875-884. doi: 10.1002/hep.24103
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Schiffer E.
The 2nd annual oncology biomarkers conference.
Biomark Med. 2009 Apr;3(2):203-9.
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Weissinger EM, Zürbig P, Ganser A.
Proteomics studies after hematopoietic stem cell transplantation.
Methods Mol Biol. 2009;506:437-52
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Schiffer E, Vlahou A, Petrolekas A, Stravodimos K, Tauber R, Geschwend JE, Neuhaus J, Stolzenburg JU, Conaway MR, Mischak H, Theodorescu D
Prediction of Muscle-invasive Bladder Cancer Using Urinary Proteomics
Clin Cancer Res. 2009 Aug 1;15(15):4935-43
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Weissinger EM, Mischak H, Kontsendorn J, Hahn A, Hahn N, Morgan M, Ganser A
Proteome analysis in hematology using capillary electrophoresis coupled on-line to mass spectrometry
Mini Rev Med Chem. 2009 May;9(5):627-3
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Schiffer E, Mischak H, Theodorescu, Vlahou A
Challenges of using mass spectrometry as a bladder cancer biomarker discovery platform
World Journal of Urology 2008, 26(1): 67-74
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Theodorescu D, Schiffer E, Bauer HW, Douwes F, Eichhorn F, Polley R, Schmidt T, Schöfer W, Zurbig P, Good DM, Coon JJ, Mischak H
Discovery and validation of urinary biomarkers for prostate cancer
PROTEOMICS - Clinical Applications 2008, 2(4): 556-570
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Schiffer E
Biomarkers for prostate cancer
World Journal of Urology 2007, 25(6): 557-562
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Wittke S, Schiffer E, Bauer HW
Kapillarelektrophorese gekoppelte Massenspektrometrie zur Proteomanalyse: Eine innovative diagnostische Methode bei Prostata- und Blasenkrebs
Der Urologe 2007, 46(7): 733-739
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Mischak H
Hochauflösende Proteomanalyse aus Urin in der nicht invasiven Diagnostik von Tumoren und chronischen Erkrankungen
prevention and anti aging 2006, 2(4): 426-435
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Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis
Lancet Oncol. 2006, 7(3): 230-240
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Theodorescu D, Fliser D, Wittke S, Mischak H, Krebs R, Walden M, Ross M, Eltze E, Bettendorf O, Wulfing C, Semjonow A
Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine
Electrophoresis. 2005, 26(14): 2797-2808
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Kolch W, Mischak H, Pitt AR
The molecular make-up of a tumour: proteomics in cancer research
Clin Sci (Lond). 2005, 108(5): 369-383
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