Scientific Articles Cardiology


Lucas-Herald AK, Zürbig P, Mason A, Kinning E, Brown CE, Mansoorian B, Mullen W, Ahmed SF, Delles C.

Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous ZMPSTE24 Mutation.

Proteomics Clin Appl. 2018 Dec 13:e1800135. doi: 10.1002/prca.201800135. [Epub ahead of print]

PMID: 30548811

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Huang QF, Van Keer J, Zhang ZY, Trenson S, Nkuipou-Kenfack E, Van Aelst LNL, Yang WY, Thijs L, Wei FF, Ciarka A, Vanhaecke J, Janssens S, Van Cleemput J, Mischak H, Staessen JA.

Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients.

PLoS One. 2018 Sep 24;13(9):e0204439. doi: 10.1371/journal.pone.0204439. ECollection 2018.

PMID: 30248148

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Huang QF, Trenson S, Zhang ZY, Van Keer J, Van Aelst LNL, Yang WY, Nkuipou-Kenfack E, Thijs L, Wei FF, Mujaj B, Ciarka A, Droogné W, Vanhaecke J, Janssens S, Van Cleemput J, Mischak H, Staessen JA.

Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study.

Transplant Direct. 2018 Apr 23;4(5):e346. doi: 10.1097/TXD.0000000000000783. eCollection 2018 May.

PMID: 29796417

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Zhang ZY, Nkuipou-Kenfack E, Yang WY, Wei FF, Cauwenberghs N, Thijs L, Huang QF, Feng YM, Schanstra JP, Kuznetsova T, Voigt JU, Verhamme P, Mischak H, Staessen JA.

Epidemiologic observations guiding clinical application of a urinary peptidomic marker of diastolic left ventricular dysfunction.

J Am Soc Hypertens. 2018 Jun;12(6):438-447.e4. doi: 10.1016/j.jash.2018.03.007. Epub 2018 Mar 21.

PMID: 29681522

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Lygirou V, Latosinska A, Makridakis M, Mullen W, Delles C, Schanstra JP, Zoidakis J, Pieske B, Mischak H, Vlahou A.

Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease.

J Transl Med. 2018 Apr 17;16(1):104. doi: 10.1186/s12967-018-1476-9.

PMID: 29665821

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Zhang ZY, Ravassa S, Nkuipou-Kenfack E, Yang WY, Kerr SM, Koeck T, Campbell A, Kuznetsova T, Mischak H, Padmanabhan S, Dominiczak AF, Delles C, Staessen JA.
Novel Urinary Peptidomic Classifier Predicts Incident Heart Failure.
J Am Heart Assoc. 2017 Aug 7;6(8). pii: e005432. doi: 10.1161/JAHA.116.005432.

PMID: 28784649

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Htun NM, Magliano DJ, Zhang ZY, Lyons J, Petit T, Nkuipou-Kenfack E, Ramirez-Torres A, von Zur Muhlen C, Maahs D, Schanstra JP, Pontillo C, Pejchinovski M, Snell-Bergeon JK, Delles C, Mischak H, Staessen JA, Shaw JE, Koeck T, Peter K.
Prediction of acute coronary syndromes by urinary proteome analysis.
PLoS One. 2017 Mar 8;12(3):e0172036. doi: 10.1371/journal.pone.0172036. eCollection 2017.

PMID: 28273075 Free PMC Article

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Albalat A, Mullen W, Husi H, Mischak H.
Tissue Proteomics in Vascular Disease.
Methods Mol Biol. 2017;1527:53-60. doi: 10.1007/978-1-4939-6625-7_4.

PMID: 28116706

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Mokou M, Lygirou V, Vlahou A, Mischak H.
Proteomics in cardiovascular disease: recent progress and clinical implication and implementation.
Expert Rev Proteomics. 2017 Feb;14(2):117-136. doi: 10.1080/14789450.2017.1274653. Epub 2017 Jan 5. Review.

PMID: 27997814

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Zhang Z, Ravassa S, Yang WY, Petit T, Petra Z, Lopez B, Wei FF, Pontillo C, Thijs L, Jacobs L, Gonzalez A, Koeck T, Christian D, Voigt JU, Verhamme P, Kuznetsova T, Diez J, Mischak H, Staessen JA.
J Hypertens. 2016 Sep;34 Suppl 2:e91-2. doi: 10.1097/01.hjh.0000491572.80267.23.

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Rossing K, Bosselmann HS, Gustafsson F, Zhang ZY, Gu YM, Kuznetsova T, Nkuipou-Kenfack E, Mischak H, Staessen JA, Koeck T, Schou M.
Urinary Proteomics Pilot Study for Biomarker Discovery and Diagnosis in Heart Failure with Reduced Ejection Fraction.
PLoS One. 2016 Jun 16;11(6):e0157167. doi: 10.1371/journal.pone.0157167. eCollection 2016.

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Zhang ZY, Thijs L, Petit T, Gu YM, Jacobs L, Yang WY, Liu YP, Koeck T, Zürbig P, Jin Y, Verhamme P, Voigt JU, Kuznetsova T, Mischak H, Staessen JA.
Urinary Proteome and Systolic Blood Pressure as Predictors of 5-Year Cardiovascular and Cardiac Outcomes in a General Population.
Hypertension. 2015 Jul;66(1):52-60. doi: 10.1161/HYPERTENSIONAHA.115.05296. Epub 2015 May 11.

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Brown CE, McCarthy NS, Hughes AD, Sever P, Stalmach A, Mullen W, Dominiczak AF, Sattar N, Mischak H, Thom S, Mayet J, Stanton AV, Delles C.
Urinary proteomic biomarkers to predict cardiovascular events.
Proteomics Clin Appl. 2015 Mar 19. doi: 10.1002/prca.201400195. [Epub ahead of print]

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Schanstra JP, Zürbig P, Alkhalaf A, Argiles A, Bakker SJ, Beige J, Bilo HJ, Chatzikyrkou C, Dakna M, Dawson J, Delles C, Haller H, Haubitz M, Husi H, Jankowski J, Jerums G, Kleefstra N, Kuznetsova T, Maahs DM, Menne J, Mullen W, Ortiz A, Persson F, Rossing P, Ruggenenti P, Rychlik I, Serra AL, Siwy J, Snell-Bergeon J, Spasovski G, Staessen JA, Vlahou A, Mischak H, Vanholder R. J
Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides.
J Am Soc Nephrol. 2015 Jan 14. pii: ASN.2014050423. [Epub ahead of print]

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Silva S, Bronze M R, Figueira M, Siwy J, Mischak H, Combet E, Mullen W
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic biomarkers of coronary artery disease, chronic kidney disease, and diabetes (types 1 and 2): a randomized, parallel, controlled, double-blind study
AJCN. First published ahead of print November 19, 2014 as doi: 10.3945/ajcn.114.094219.

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Stalmach A, Husi H, Mosbahi K, Albalat A, Mullen W, Mischak H.
Methods in capillary electrophoresis coupled to mass spectrometry for the identification of clinical proteomic/peptidomic biomarkers in biofluids.
Methods Mol Biol. 2015;1243:187-205. doi: 10.1007/978-1-4939-1872-0_11.


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Zhang Z, Staessen JA, Thijs L, Gu Y, Liu Y, Jacobs L, Koeck T, Zürbig P, Mischak H, Kuznetsova T.
Left ventricular diastolic function in relation to the urinary proteome: A proof-of-concept study in a general population.
Int J Cardiol. 2014 Jul 12. pii: S0167-5273(14)01206-6. doi: 10.1016/j.ijcard.2014.07.014. [Epub ahead of print]

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Husi H, Van Agtmael T, Mullen W, Bahlmann FH, Schanstra JP, Vlahou A, Delles C, Perco P, Mischak H.
Proteome-Based Systems Biology Analysis of the Diabetic Mouse Aorta Reveals Major Changes in Fatty Acid Biosynthesis as Potential Hallmark in Diabetes Associated Vascular Disease.
Circ Cardiovasc Genet. 2014 Feb 26. [Epub ahead of print]

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Mansor R, Mullen W, Albalat A, Zerefos P, Mischak H, Barrett DC, Biggs A, Eckersall PD
A peptidomic approach to biomarker discovery for bovine mastitis.
J Proteomics. 2013 Jun 24;85:89-98. doi: 10.1016/j.jprot.2013.04.027. Epub 2013 Apr 30.

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 Carty DM, Schiffer E, Delles C.
 Proteomics in hypertension
J Hum Hypertens. 2013 Apr;27(4):211-6. doi: 10.1038/jhh.2012.30. Epub 2012 Aug 9
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 Kuznetsova T, Mischak H, Mullen W, Staessen JA
Urinary proteome analysis in hypertensive patients with left ventricular diastolic dysfunction.
Eur Heart J. 2012 Sep;33(18):2342-50. Epub 2012 Jul 11.
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Dawson J, Walters M, Delles C, Mischak H, Mullen W.
Urinary proteomics to support diagnosis of stroke.
PLoS One. 2012;7(5):e35879. Epub 2012 May 16.
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Mullen W, Gonzalez J, Siwy J, Franke J, Sattar N, Mullan A, Roberts S, Delles C, Mischak H, Albalat A.
A Pilot Study on the Effect of Short-Term Consumption of a Polyphenol Rich Drink on Biomarkers of Coronary Artery Disease Defined by Urinary Proteomics.
J Agric Food Chem. 2011 Dec 28;59(24):12850-7
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Carty DM, Siwy J, Brennand JE, Zürbig P, Mullen W, Franke J, McCulloch JW, North RA, Chappell LC, Mischak H, Poston L, Dominiczak AF, Delles C.
Urinary Proteomics for Prediction of Preeclampsia.
Hypertension. 2011 Mar;57(3):561-9
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Delles C, Schiffer E, von zur Muhlen C, Peter K, Rossing P, Parving HH, Dymott JA a, Neisius U, Zimmerli LUa, Snell-Bergeon JK, Maahs DM, Schmieder RE, Mischak H, Dominiczak AF
Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 subjects
J Hypertension
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Muhlen C, Schiffer E, Zuerbig P, Kellmann M, Brasse M, Meert N, Vanholder RC, Dominiczak AF, Chen YC, Mischak H, Bode C, Peter K
Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients
Journal of Proteome Research 2009, 8(1): 335-345
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Snell-Bergeon JK, Maahs DM, Ogden LG, Kinney GL, Hokanson JE, Schiffer E, Mischak H, Rewers M
Evaluation of urinary biomarkers for coronary artery disease, diabetes, and diabetic kidney disease
Diabetes, Technology and Therapeutics 2009, 11(1): 1-9
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Zimmerli LU, Schiffer E, Zurbig P, Good DM, Kellmann M, Mouls L, Pitt AR, Coon JJ, Schmieder RE, Peter K, Mischak H, Kolch W, Delles C, Dominiczak AF
Urinary proteomic biomarkers in coronary artery disease
Mol Cell Proteomics 2008, 7(2): 290-298
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Geppert HG, von zur Mühlen C, Mischak H
Proteomanalyse zur Erkennung und Therapieevaluierung der koronaren Herzkrankheit
journal of preventive medicine 2007, 3(2): 160-168
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