Publications 2021
388.
Mengual L, Frantzi M, Mokou M, Ingelmo-Torres M, Vlaming M, Merseburger AS, Roesch MC, Culig Z, Alcaraz A, Vlahou A, Mischak H, Van der Heijden AG.
A prospective validation of nomograms based on BC-116 and BC-106 urine peptide biomarker panels for bladder cancer diagnostics and monitoring.
medRxiv preprint server 2021.
387.
Rönkkö TKE, Eickhoff MK, Mischak H, Rossing P, Persson F, Ahluwalia TS
202: Urinary proteomics and the effect of dapagliflozin treatment in persons with type 2 diabetes and diabetic kidney disease: a randomised crossover trial.
Diabetologia (2021) 64 (Suppl 1):S106
doi: 10.1007/s00125-021-05519-y#Sec34
386.
Siwy J, Wendt R, Albalat A, He T, Mischak H, Mullen W, Latosińska A, Lübbert C, Kalbitz S, Mebazaa A, Peters B, Stegmayr B, Spasovski G, Wiech T, Staessen JA, Wolf J, Beige J.
Critical COVID-19 represents an endothelial disease with similarity to kidney disease on the molecular level.
medRxiv preprint server 2021.
doi: 10.1101/2021.02.22.21252207
385.
Stroggilos R, Frantzi M, Zoidakis J, Mavrogeorgis E, Mokou M, Melidi A, Roubelakis MG, Mischak H, Vlahou A.
O14: Gene expression and coexpression analysis of the entire bladder cancer clinical stage spectrum.
Eur Urol Open Sci 2021;32(Suppl 2):S180
doi: 10.1016/S2666-1683(21)01200-3
384.
Wei DM, Trenson T, Van Keer JM, Melgarejo J, Thijs L, He TL, Latosinska A, Vanassche T, Van Aelst L, Janssens S, Van Cleemput J, Mischak H, Staessen JA, Verhamme P, Zhang ZY.
The novel proteomic signature for the detection of cardiac allograft vasculopathy.
European Heart Journal 2021, 42, ehab724-3391.
doi: 10.1093/eurheartj/ehab724.3391
383.
Wei DM, Melgarejo J, Thijs L, Ciarka A, Vanassche T, Van Aelst L, Janssens S, Mischak H, Staessen JA, Verhamme P.
The urinary proteomic profile of arterial stiffness in the general population.
European Heart Journal 2021, 42, ehab724-3392.
doi: 10.1093/eurheartj/ehab724.3392
382.
Rudnicki M, Siwy J, Wendt R, Lipphardt M, Koziolek MJ, Maixnerova D, Peters B, Kerschbaum J, Leierer J, Neprasova M, Banasik M, Sanz AB, Perez-Gomez MV, Ortiz A, Stegmayr B, Tesar V, Mischak H, Beige J, Reich HN, PERSTIGAN working group.
Urine proteomics for prediction of disease progression in patients with IgA nephropathy.
Nephrol Dial Transplant. 2021, Dec 31;37(1):42-52. doi: 10.1093/ndt/gfaa307.
PMID: 33313853
View Abstract: 
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381.
Mavrogeorgis E, Mischak H, Latosinska A, Vlahou A, Schanstra JP, Siwy J, Jankowski V, Beige J, Jankowski J.
Collagen-Derived Peptides in CKD: A Link to Fibrosis.
Toxins (Basel). 2021 Dec 23;14(1):10. doi: 10.3390/toxins14010010.
PMID: 35050988
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380.
Sanchez-Martin I, Magalhães P, Ranjzad P, Fatmi A, Richard F, Manh TPV, Saurin AJ, Feuillet G, Denis C, Woolf AS, Schanstra JP, Zürbig P, Caubit X, Fasano L.
Haploinsufficiency of the mouse Tshz3 gene leads to kidney defects.
Hum Mol Genet. 2021 Dec 17:ddab362. doi: 10.1093/hmg/ddab362. Online ahead of print.
PMID: 34919690
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379.
Wendt R, Siwy J, He T, Latosinska A, Wiech T, Zipfel PF, Tserga A, Vlahou A, Rupprecht H, Catanese L, Mischak H, Beige J.
Molecular Mapping of Urinary Complement Peptides in Kidney Diseases.
Proteomes. 2021 Dec 13;9(4):49. doi: 10.3390/proteomes9040049.
PMID: 34941814
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378.
Mavrogeorgis E, Mischak H, Latosinska A, Siwy J, Jankowski V, Jankowski J.
Reproducibility Evaluation of Urinary Peptide Detection Using CE-MS.
Molecules. 2021 Nov 30;26(23):7260. doi: 10.3390/molecules26237260.
PMID: 34885840
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377.
Martens DS, Thijs L, Latosinska A, Trenson S, Siwy J, Zhang ZY, Wang C, Beige J, Vlahou A, Janssens S, Mischak H, Nawrot TS, Staessen JA.
Urinary peptidomic profiles to address age-related disabilities: a prospective population study.
FLEMENGHO investigators.Lancet Healthy Longev. 2021 Nov;2(11):e690-e703. doi: 10.1016/S2666-7568(21)00226-9.
PMID: 34766101
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376.
He T, Mischak M, Clark AL, Campbell RT, Delles C, Díez J, Filippatos G, Mebazaa A, McMurray JJV, González A, Raad J, Stroggilos R, Bosselmann HS, Campbell A, Kerr SM, Jackson CE, Cannon JA, Schou M, Girerd N, Rossignol P, McConnachie A, Rossing K, Schanstra JP, Zannad F, Vlahou A, Mullen W, Jankowski V, Mischak H, Zhang Z, Staessen JA, Latosinska A.
Urinary peptides in heart failure: a link to molecular pathophysiology.
Eur J Heart Fail. 2021 Nov;23(11):1875-1887. doi: 10.1002/ejhf.2195. Epub 2021 May 7.
PMID: 33881206
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375.
Rambabova-Bushljetik I, Metzger J, Siwy J, Dohcev S, Bushljetikj O, Filipce V, Trajceska L, Mischak H, Spasovski G.
Association of the chronic kidney disease urinary proteomic predictor CKD273 with clinical risk factors of graft failure in kidney allograft recipients.
Nephrol Dial Transplant. 2021 Oct 11:gfab297. doi: 10.1093/ndt/gfab297. Online ahead of print.
PMID: 34634117
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374.
Aiquel LL, Pitta J, Antonoglou GN, Mischak I, Sailer I, Payer M.
Does the timing of implant placement and loading influence biological outcomes of implant-supported multiple-unit fixed dental prosthesis-A systematic review with meta-analyses.
Clin Oral Implants Res. 2021 Oct;32 Suppl 21:5-27. doi: 10.1111/clr.13860.
PMID: 34642990 Review.
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373.
Latosinska A, Siwy J, Cherney DZ, Perkins BA, Mischak H, Beige J.
SGLT2-Inhibition reverts urinary peptide changes associated with severe COVID-19: An in-silico proof-of-principle of proteomics-based drug repurposing.
Proteomics. 2021 Oct;21(20):e2100160. doi: 10.1002/pmic.202100160. Epub 2021 Sep 15.
PMID: 34477316
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372.
Thijs L, Asayama K, Maestre GE, Hansen TW, Buyse L, Wei DM, Melgarejo JD, Brguljan-Hitij J, Cheng HM, de Souza F, Gilis-Malinowska N, Kawecka-Jaszcz K, Mels C, Mokwatsi G, Muxfeldt ES, Narkiewicz K, Odili AN, Rajzer M, Schutte AE, Stolarz-Skrzypek K, Tsai YW, Vanassche T, Vanholder R, Zhang ZY, Verhamme P, Kruger R, Mischak H, Staessen JA, UPRIGHT-HTM Investigators; Coordinating, Logistic, Recruiting, and Urinary Proteomics Centres & Advisors.
Urinary proteomics combined with home blood pressure telemonitoring for health care reform trial: rational and protocol.
Blood Press. 2021 Oct;30(5):269-281. doi: 10.1080/08037051.2021.1952061. Epub 2021 Aug 30.
PMID: 34461803
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371.
Siwy J, Wendt R, Albalat A, He T, Mischak H, Mullen W, Latosinska A, Lübbert C, Kalbitz S, Mebazaa A, Peters B, Stegmayr B, Spasovski G, Wiech T, Staessen JA, Wolf J, Beige J.
CD99 and polymeric immunoglobulin receptor peptides deregulation in critical COVID-19: A potential link to molecular pathophysiology?
Proteomics. 2021 Oct;21(20):e2100133. doi: 10.1002/pmic.202100133. Epub 2021 Aug 21.
PMID: 34383378
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370.
Curovic VR, Magalhães P, He T, Hansen TW, Mischak H, Rossing P, DIRECT Programme Study Group.
Urinary peptidome and diabetic retinopathy in the DIRECT-Protect 1 and 2 trials.
Diabet Med. 2021 Sep;38(9):e14634. doi: 10.1111/dme.14634. Epub 2021 Jul 18.
PMID: 34228837 Clinical Trial.
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369.
Petra E, He T, Lygirou V, Latosinska A, Mischak H, Vlahou A, Jankowski J.
Urine peptidome analysis in cardiorenal syndrome reflects molecular processes.
Sci Rep. 2021 Aug 10;11(1):16219. doi: 10.1038/s41598-021-95695-z.
PMID: 34376786
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368.
Bannaga A, Metzger J, Voigtländer T, Pejchinovski M, Frantzi M, Book T, James S, Gopalakrishnan K, Mischak H, Manns MP, Arasaradnam RP.
Pathophysiological Implications of Urinary Peptides in Hepatocellular Carcinoma.
Cancers (Basel). 2021 Jul 27;13(15):3786. doi: 10.3390/cancers13153786.
PMID: 34359689
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367.
Catanese L, Siwy J, Mavrogeorgis E, Amann K, Mischak H, Beige J, Rupprecht H.
A Novel Urinary Proteomics Classifier for Non-Invasive Evaluation of Interstitial Fibrosis and Tubular Atrophy in Chronic Kidney Disease.
Proteomes. 2021 Jul 13;9(3):32. doi: 10.3390/proteomes9030032.
PMID: 34287333
View Abstract: Free PMC article. Request Reprint
366.
Hupe MC, Hempel MC, Rodler S, Frantzi M, Mischak H, Merseburger AS, Stief CG, Chaloupka M.
[Diagnostic markers in urology].
Free PMC article. Request Reprint
365.
Mokou M, Frantzi M, Mischak H, Vlahou A, Latosinska A.
Developing novel drug candidates and repurposed drugs for prostate cancer based on molecular profiles.
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364.
Wendt R, Thijs L, Kalbitz S, Mischak H, Siwy J, Raad J, Metzger J, Neuhaus B, Leyen HV, Dudoignon E, Mebazaa A, Spasovski G, Milenkova M, Canevska-Talevska A, Czerwieńska B, Wiecek A, Peters B, Nilsson Å, Schwab M, Rothfuss K, Lübbert C, Staessen JA, Beige J, CRIT-COV-U investigators.
A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients.
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363.
Niborski LL, Paces-Fessy M, Ricci P, Bourgeois A, Magalhães P, Kuzma-Kuzniarska M, Lesaulnier C, Reczko M, Declercq E, Zürbig P, Doucet A, Umbhauer M, Cereghini S.
Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.
Free PMC article. Request ReprintTailliar M, Schanstra JP, Dierckx T, Breuil B, Hanouna G, Charles N, Bascands JL, Dussol B, Vazi A, Chiche L, Siwy J, Faguer S, Daniel L, Daugas E, Jourde-Chiche N, On Behalf Of The Groupe Coopératif Sur le Lupus Rénal Gclr.
Urinary Peptides as Potential Non-Invasive Biomarkers for Lupus Nephritis: Results of the Peptidu-LUP Study.
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361.
Siwy J, Mischak H, Beige J, Rossing P, Stegmayr B.
Biomarkers for early detection of kidney disease: a call for pathophysiological relevance.
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360.
He T, Mischak M, Clark AL, Campbell RT, Delles C, Díez J, Filippatos G, Mebazaa A, McMurray JJV, González A, Raad J, Stroggilos R, Bosselmann HS, Campbell A, Kerr SM, Jackson CE, Cannon JA, Schou M, Girerd N, Rossignol P, McConnachie A, Rossing K, Schanstra JP, Zannad F, Vlahou A, Mullen W, Jankowski V, Mischak H, Zhang Z, Staessen JA, Latosinska A.
Urinary peptides in heart failure: a link to molecular pathophysiology.
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359.
He T, Zhang Z, Staessen JA, Mischak H, Latosinska A, Beige J.
Proteomic Biomarkers in the Cardiorenal Syndrome: Toward Deciphering Molecular Pathophysiology.
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358.
Verbeke F, Siwy J, Van Biesen W, Mischak H, Pletinck A, Schepers E, Neirynck N, Magalhães P, Pejchinovski M, Pontillo C, Lichtinghagen R, Brand K, Vlahou A, De Bacquer D, Glorieux G.
View Abstract: Free PMC article. Request Reprint
357.
Mavrogeorgis E, Mischak H, Beige J, Latosinska A, Siwy J.
Understanding glomerular diseases through proteomics.
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356.
Gomez-Cabrero D, Walter S, Abugessaisa I, Miñambres-Herraiz R, Palomares LB, Butcher L, Erusalimsky JD, Garcia-Garcia FJ, Carnicero J, Hardman TC, Mischak H, Zürbig P, Hackl M, Grillari J, Fiorillo E, Cucca F, Cesari M, Carrie I, Colpo M, Bandinelli S, Feart C, Peres K, Dartigues JF, Helmer C, Viña J, Olaso G, García-Palmero I, Martínez JG, Jansen-Dürr P, Grune T, Weber D, Lippi G, Bonaguri C, Sinclair AJ, Tegner J, Rodriguez-Mañas L, FRAILOMIC initiative.
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts.
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355.
Vlahou A, Hallinan D, Apweiler R, Argiles A, Beige J, Benigni A, Bischoff R, Black PC, Boehm F, Céraline J, Chrousos GP, Delles C, Evenepoel P, Fridolin I, Glorieux G, van Gool AJ, Heidegger I, Ioannidis JPA, Jankowski J, Jankowski V, Jeronimo C, Kamat AM, Masereeuw R, Mayer G, Mischak H, Ortiz A, Remuzzi G, Rossing P, Schanstra JP, Schmitz-Dräger BJ, Spasovski G, Staessen JA, Stamatialis D, Stenvinkel P, Wanner C, Williams SB, Zannad F, Zoccali C, Vanholder R.
Data Sharing Under the General Data Protection Regulation: Time to Harmonize Law and Research Ethics?
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354.
Magalhães P, Zürbig P, Mischak H, Schleicher E.
Urinary fetuin-A peptides as a new marker for impaired kidney function in patients with type 2 diabetes.
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353.
Vanholder R, Argilés A, Jankowski J; European Uraemic Toxin Work Group (EUTox).
A history of uraemic toxicity and of the European Uraemic Toxin Work Group.
Clin Kidney J. 2021 Jan 24;14(6):1514-1523. doi: 10.1093/ckj/sfab011. eCollection 2021 Jun.
PMID: 34413975
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352.
He T, Melgarejo JD, Clark AL, Yu YL, Thijs L, Díez J, López B, González A, Cleland JG, Schanstra JP, Vlahou A, Latosinska A, Mischak H, Staessen JA, Zhang ZY, Jankowski V.
Serum and urinary biomarkers of collagen type-I turnover predict prognosis in patients with heart failure.
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