Publications 2019


Verbeke F, Siwy J, Van Biesen W, Mischak H, Pletinck A, Schepers E, Neirynck N, Magalhães P, Pejchinovski M, Pontillo C, Lichtinghagen R, Brand K, Vlahou A, De Bacquer D, Glorieux G.

The urinary proteomics classifier chronic kidney disease 273 predicts cardiovascular outcome in patients with chronic kidney disease.

Nephrol Dial Transplant. 2019 Dec 14:gfz242. doi: 10.1093/ndt/gfz242. Online ahead of print.

PMID: 31837226

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Zürbig P, Siwy J, Mischak H.

Emerging urine-based proteomic biomarkers as valuable tools in the management of chronic kidney disease.

Expert Rev Mol Diagn. 2019 Oct;19(10):853-856. doi: 10.1080/14737159.2019.1657406. Epub 2019 Aug 21.

PMID: 31423855

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Valiño-Rivas L, Cuarental L, Agustin M, Husi H, Cannata-Ortiz P, Sanz AB, Mischak H, Ortiz A, Sanchez-Niño MD

MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells.

Nephrol Dial Transplant. 2019 Sep 1;34(9):1498-1507. doi: 10.1093/ndt/gfy367.

PMID: 30541139

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Belczacka I, Latosinska A, Siwy J, Metzger J, Merseburger AS, Mischak H, Vlahou A, Frantzi M, Jankowski V.

Author Correction: Urinary CE-MS peptide marker pattern for detection of solid tumors.

Sci Rep. 2019 Sep 3;9(1):12864. doi: 10.1038/s41598-019-49304-9.

PMID: 31477787

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Siwy J, Mischak H, Zürbig P.

Proteomics and personalized medicine: a focus on kidney disease.

Expert Rev Proteomics. 2019 Sep;16(9):773-782. doi: 10.1080/14789450.2019.1659138. Epub 2019 Aug 23.

PMID: 31441341

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Huang QF, Zhang ZY, Van Keer J, Trenson S, Nkuipou-Kenfack E, Yang WY, Thijs L, Vanhaecke J, Van Aelst LNL, Van Cleemput J, Janssens S, Verhamme P, Mischak H, Staessen JA.

Urinary peptidomic biomarkers of renal function in heart transplant recipients.

Nephrol Dial Transplant. 2019 Aug 1;34(8):1336-1343. doi: 10.1093/ndt/gfy185.

PMID: 29982668

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Vinel C, Schanstra JP, Boizard F, Péreira O, Auriau J, Dortignac A, Breuil B, Feuillet G, Nkuipou-Kenfack E, Zürbig P, Valet P, Bascands JL, Dray C, Denis C.

Apelin affects the mouse aging urinary peptidome with minimal effects on kidney.

Sci Rep. 2019 Jul 23;9(1):10647. doi: 10.1038/s41598-019-47109-4.

PMID: 31337837

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Pelander L, Brunchault V, Buffin-Meyer B, Klein J, Breuil B, Zürbig P, Magalhães P, Mullen W, Elliott J, Syme H, Schanstra JP, Häggström J, Ljungvall I.

Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs.

Vet J. 2019 Jul;249:73-79. doi: 10.1016/j.tvjl.2019.05.010. Epub 2019 May 27.

PMID: 31239169

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Belczacka I, Pejchinovski M, Krochmal M, Magalhães P, Frantzi M, Mullen W, Vlahou A, Mischak H, Jankowski

Urinary Glycopeptide Analysis for the Investigation of Novel Biomarkers.

Proteomics Clin Appl. 2019 May;13(3):e1800111. doi: 10.1002/prca.201800111. Epub 2018 Oct 18.

PMID: 30334612

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Krochmal M, van Kessel KEM, Zwarthoff EC, Belczacka I, Pejchinovski M, Vlahou A, Mischak H, Frantzi M.

Urinary peptide panel for prognostic assessment of bladder cancer relapse.

Sci Rep. 2019 May 21;9(1):7635. doi: 10.1038/s41598-019-44129-y.

PMID: 31114012

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Ferreira JP, Verdonschot J, Collier T, Wang P, Pizard A, Bär C, Björkman J, Boccanelli A, Butler J, Clark A, Cleland JG, Delles C, Diez J, Girerd N, González A, Hazebroek M, Huby AC, Jukema W, Latini R, Leenders J, Levy D, Mebazaa A, Mischak H, Pinet F, Rossignol P, Sattar N, Sever P, Staessen JA, Thum T, Vodovar N, Zhang ZY, Heymans S, Zannad F.

Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure.

Circ Heart Fail. 2019 May;12(5):e005897. doi: 10.1161/CIRCHEARTFAILURE.118.005897.

PMID: 31104495

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Frantzi M, Gomez Gomez E, Blanca Pedregosa A, Valero Rosa J, Latosinska A, Culig Z, Merseburger AS, Luque RM, Requena Tapia MJ, Mischak H, Carrasco Valiente J.

CE-MS-based urinary biomarkers to distinguish non-significant from significant prostate cancer.

Br J Cancer. 2019 May 16. doi: 10.1038/s41416-019-0472-z. [Epub ahead of print]

PMID: 31092909

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Schanstra JP, Luong TT, Makridakis M, Van Linthout S, Lygirou V, Latosinska A, Alesutan I, Boehme B, Schelski N, Von Lewinski D, Mullen W, Nicklin S, Delles C, Feuillet G, Denis C, Lang F, Pieske B, Bascands JL, Mischak H, Saulnier-Blache JS, Voelkl J, Vlahou A, Klein J.

Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

JCI Insight. 2019 May 16;4(10). pii: 125638. doi: 10.1172/jci.insight.125638. eCollection 2019 May 16.

PMID: 31092728

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Latosinska A, Siwy J, Mischak H, Frantzi M.

Peptidomics and Proteomics based on CE-MS as a robust tool in clinical application: The past, the present, and the future.

Electrophoresis. 2019 May 3. doi: 10.1002/elps.201900091. [Epub ahead of print]

PMID: 31054149

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Zhang ZY, Nkuipou-Kenfack E, Staessen JA.

Urinary Peptidomic Biomarker for Personalized Prevention and Treatment of Diastolic Left Ventricular Dysfunction.

Proteomics Clin Appl. 2019 Mar;13(2):e1800174. doi: 10.1002/prca.201800174. Epub 2019 Feb 18.

PMID: 30632674

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Paczesny S, Metzger J.

Clinical Proteomics for Post-Hematopoeitic Stem Cell Transplantation Outcomes.

Proteomics Clin Appl. 2019 Mar;13(2):e1800145. doi: 10.1002/prca.201800145. Epub 2018 Oct 17.

PMID: 30307119

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Tianlin He

Implementation of Proteomics in Clinical Trials

Proteomics Clin Appl. 2019 Mar;13(2):e1800198. doi:  10.1002/prca.201800198. Epub 2019 Feb 12.

PMID: 30702805

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Frantzi M, Latosinska A, Mischak H.

Proteomics in Drug Development: the Dawn of a New Era?

Proteomics Clin Appl. 2019Mar;13(2):e1800087. doi: 10.1002/prca.201800087. Epub 2019 Feb 25.

PMID: 30724014

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Lucas-Herald AK, Zürbig P, Mason A, Kinning E, Brown CE, Mansoorian B, Mullen W, Ahmed SF, Delles C.

Proteomic Evidence of Biological Aging in a Child with a Compound Heterozygous ZMPSTE24 Mutation.

Proteomics Clin Appl. 2019 Mar;13(2):e1800135. doi: 10.1002/prca.201800135. Epub 2018 Dec 27.

PMID: 30548811

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Weidemann F, Beer M, Kralewski M, Siwy J, Kampmann C.

Early detection of organ involvement in Fabry disease by biomarker assessment in conjunction with LGE cardiac MRI: results from the SOPHIA study.

Weidemann F, Beer M, Kralewski M, Siwy J, Kampmann C. Mol Genet Metab. 2019 Feb;126(2):169-182. doi: 10.1016/j.ymgme.2018.11.005. Epub 2018 Nov 12.

PMID: 30594474

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Mokou M, Klein J, Makridakis M, Bitsika V, Bascands JL, Saulnier-Blache JS, Mullen W, Sacherer M, Zoidakis J, Pieske B, Mischak H, Roubelakis MG, Schanstra JP, Vlahou A.

Proteomics based identification of KDM5 histone demethylases associated with cardiovascular disease.

EBioMedicine. 2019 Feb 27. pii: S2352-3964(19)30118-5. doi: 10.1016/j.ebiom.2019.02.040. [Epub ahead of print]

PMID: 30826357

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Ricci P, Magalhães P, Krochmal M, Pejchinovski M, Daina E, Caruso MR, Goea L, Belczacka I, Remuzzi G, Umbhauer M, Drube J, Pape L, Mischak H, Decramer S, Schaefer F, Schanstra JP, Cereghini S, Zürbig P.

Urinary proteome signature of Renal Cysts and Diabetes syndrome in children.

Sci Rep. 2019 Feb 18;9(1):2225. doi: 10.1038/s41598-019-38713-5.

PMID: 30778115

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Frantzi M, Mischak H, Latosinska A.

Clinical proteomics on the path towards implementation: first promises delivered.

Proteomics Clin Appl. 2019 Feb 14:e1800094. doi: 10.1002/prca.201800094. [Epub ahead of print] No abstract available.

PMID: 30767399

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Marx D, Metzger J, Olagne J, Belczacka I, Faguer S, Colombat M, Husi H, Mullen W, Gwinner W, Caillard S.

Proteomics in kidney allograft transplantation - Application of molecular pathway analysis for kidney allograft disease phenotypic biomarker selection.

Proteomics Clin Appl. 2019 Jan 25:e1800091. doi: 10.1002/prca.201800091. [Epub ahead of print] Review.

PMID: 30680934

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Siwy J, Klein T, Rosler M, von Eynatten M.

Urinary Proteomics as a tool to Identify Kidney Responders to Dipeptidyl Peptidase-4 Inhibition. A Hypothesis-Generating Analysis from the MARLINA-T2D Trial.

Proteomics Clin Appl. 2019 Jan 11:e1800144. doi: 10.1002/prca.201800144. [Epub ahead of print]

PMID: 30632692

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Frantzi M, Latosinska A, Belczacka I, Mischak H.

Urinary proteomic biomarkers in oncology: ready for implementation?

Expert Rev Proteomics. 2019 Jan;16(1):49-63. doi: 10.1080/14789450.2018.1547193. Epub 2018 Nov 15.

PMID: 30412678

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Kanzelmeyer NK, Zürbig P, Mischak H, Metzger J, Fichtner A, Ruszai KH, Seemann T, Hansen M, Wygoda S, Krupka K, Tönshoff B, Melk A, Pape L.

Urinary proteomics to diagnose chronic active antibody-mediated rejection in pediatric kidney transplantation - a Pilot study.

Transpl Int. 2019 Jan;32(1):28-37. doi: 10.1111/tri.13363. Epub 2018 Nov 12.

PMID: 30357927

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Duranton F, Laget J, Gayrard N, Saulnier-Blache JS, Lundin U, Schanstra JP, Mischak H, Weinberger KM, Servel MF, Argilés A.

The CKD plasma lipidome varies with disease severity and outcome.

J Clin Lipidol. 2019 Jan-Feb;13(1):176-185.e8. doi: 10.1016/j.jacl.2018.07.010. Epub 2018 Aug 1.

PMID: 30177483

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Zürbig P, Mischak H, Menne J, Haller H.

CKD273 Enables Efficient Prediction of Diabetic Nephropathy in Nonalbuminuric Patients.

Diabetes Care. 2019 Jan;42(1):e4-e5. doi: 10.2337/dc18-1322. Epub 2018 Nov 19.

PMID: 30455331

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Belczacka I, Latosinska A, Metzger J, Marx D, Vlahou A, Mischak H, Frantzi M.

Proteomics biomarkers for solid tumors: Current status and future prospects.

Belczacka I, Latosinska A, Metzger J, Marx D, Vlahou A, Mischak H, Frantzi M. Mass Spectrom Rev. 2019 Jan;38(1):49-78. doi: 10.1002/mas.21572. Epub 2018 Jun 11.

PMID: 29889308

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