1: Frantzi M, Klimou Z, Makridakis M, Zoidakis J, Latosinska A, Borràs DM,
Janssen B, Giannopoulou I, Lygirou V, Lazaris AC, Anagnou NP, Mischak H,
Roubelakis MG, Vlahou A. Silencing of Profilin-1 suppresses cell adhesion and
tumor growth via predicted alterations in integrin and Ca2+ signaling in
T24M-based bladder cancer models. Oncotarget. 2016 Sep 23. doi:
10.18632/oncotarget.12218. [Epub ahead of print] PubMed PMID: 27683119.

2: Ortiz A, Husi H, Gonzalez-Lafuente L, Valiño-Rivas L, Fresno M, Sanz AB,
Mullen W, Albalat A, Mezzano S, Vlahou T, Mischak H, Sanchez-Niño MD.
Mitogen-Activated Protein Kinase 14 Promotes AKI. J Am Soc Nephrol. 2016 Sep 12.
pii: ASN.2015080898. [Epub ahead of print] PubMed PMID: 27620989.

3: Krochmal M, Fernandes M, Filip S, Pontillo C, Husi H, Zoidakis J, Mischak H,
Vlahou A, Jankowski J. PeptiCKDdb-peptide- and protein-centric database for the
investigation of genesis and progression of chronic kidney disease. Database
(Oxford). 2016 Sep 1;2016. pii: baw128. doi: 10.1093/database/baw128. Print 2016.
PubMed PMID: 27589965; PubMed Central PMCID: PMC5009324.

4: Magalhães P, Mischak H, Zürbig P. Urinary proteomics using capillary
electrophoresis coupled to mass spectrometry for diagnosis and prognosis in
kidney diseases. Curr Opin Nephrol Hypertens. 2016 Aug 31. [Epub ahead of print]
PubMed PMID: 27584928.

5: Klein J, Ramirez-Torres A, Ericsson A, Huang Y, Breuil B, Siwy J, Mischak H,
Peng XR, Bascands JL, Schanstra JP. Urinary peptidomics provides a noninvasive
humanized readout of diabetic nephropathy in mice. Kidney Int. 2016
Nov;90(5):1045-1055. doi: 10.1016/j.kint.2016.06.023. PubMed PMID: 27528550.

6: Zhang Z, Ravassa S, Yang WY, Petit T, Petra Z, Lopez B, Wei FF, Pontillo C,
Thijs L, Jacobs L, Gonzalez A, Koeck T, Christian D, Voigt JU, Verhamme P,
Kuznetsova T, Diez J, Mischak H, Staessen JA. [OP.7C.07] DIASTOLIC LEFT
BIOMARKERS IN A GENERAL POPULATION. J Hypertens. 2016 Sep;34 Suppl 2:e91-2. doi:
10.1097/01.hjh.0000491572.80267.23. PubMed PMID: 27508839.

7: Currie G, Flynn J, Lindhardt M, Mischak H, Rossing P, Delles C. [OP.1D.10] THE
Sep;34 Suppl 2:e14. doi: 10.1097/01.hjh.0000491365.78962.52. PubMed PMID:

8: Lindhardt M, Persson F, Zürbig P, Stalmach A, Mischak H, de Zeeuw D, Lambers
Heerspink H, Klein R, Orchard T, Porta M, Fuller J, Bilous R, Chaturvedi N,
Parving HH, Rossing P. Urinary proteomics predict onset of microalbuminuria in
normoalbuminuric type 2 diabetic patients, a sub-study of the DIRECT-Protect 2
study. Nephrol Dial Transplant. 2016 Aug 8. pii: gfw292. [Epub ahead of print]
PubMed PMID: 27507891.

9: Pontillo C, Jacobs L, Staessen JA, Schanstra JP, Rossing P, Heerspink HJ, Siwy
J, Mullen W, Vlahou A, Mischak H, Vanholder R, Zürbig P, Jankowski J. A urinary
proteome-based classifier for the early detection of decline in glomerular
filtration. Nephrol Dial Transplant. 2016 Jul 6. pii: gfw239. [Epub ahead of
print] PubMed PMID: 27387473.

10: Pejchinovski M, Siwy J, Metzger J, Dakna M, Mischak H, Klein J, Jankowski V,
Bae KT, Chapman AB, Kistler AD. Urine peptidome analysis predicts risk of
end-stage renal disease and reveals proteolytic pathways involved in autosomal
dominant polycystic kidney disease progression. Nephrol Dial Transplant. 2016 Jul
5. pii: gfw243. [Epub ahead of print] PubMed PMID: 27382111.

11: Bhat A, Mokou M, Zoidakis J, Jankowski V, Vlahou A, Mischak H. BcCluster: A
Bladder Cancer Database at the Molecular Level. Bladder Cancer. 2016 Jan
7;2(1):65-76. PubMed PMID: 27376128; PubMed Central PMCID: PMC4927921.

12: Pena MJ, Mischak H, Heerspink HJ. Proteomics for prediction of disease
progression and response to therapy in diabetic kidney disease. Diabetologia.
2016 Sep;59(9):1819-31. doi: 10.1007/s00125-016-4001-9. Epub 2016 Jun 25. Review.
PubMed PMID: 27344310; PubMed Central PMCID: PMC4969331.

13: Rossing K, Bosselmann HS, Gustafsson F, Zhang ZY, Gu YM, Kuznetsova T,
Nkuipou-Kenfack E, Mischak H, Staessen JA, Koeck T, Schou M. Urinary Proteomics
Pilot Study for Biomarker Discovery and Diagnosis in Heart Failure with Reduced
Ejection Fraction. PLoS One. 2016 Jun 16;11(6):e0157167. doi:
10.1371/journal.pone.0157167. eCollection 2016. PubMed PMID: 27308822; PubMed
Central PMCID: PMC4911082.

14: Metzger J, Mullen W, Husi H, Stalmach A, Herget-Rosenthal S, Groesdonk HV,
Mischak H, Klingele M. Acute kidney injury prediction in cardiac surgery patients
by a urinary peptide pattern: a case-control validation study. Crit Care. 2016
May 26;20(1):157. doi: 10.1186/s13054-016-1344-z. PubMed PMID: 27230659; PubMed
Central PMCID: PMC4882859.

15: Farmakis D, Koeck T, Mullen W, Parissis J, Gogas BD, Nikolaou M, Lekakis J,
Mischak H, Filippatos G. Urine proteome analysis in heart failure with reduced
ejection fraction complicated by chronic kidney disease: feasibility, and
clinical and pathogenetic correlates. Eur J Heart Fail. 2016 Jul;18(7):822-9.
doi: 10.1002/ejhf.544. Epub 2016 May 25. PubMed PMID: 27220540.

16: Latosinska A, Makridakis M, Frantzi M, Borràs DM, Janssen B, Mullen W,
Zoidakis J, Merseburger AS, Jankowski V, Mischak H, Vlahou A. Integrative
analysis of extracellular and intracellular bladder cancer cell line proteome
with transcriptome: improving coverage and validity of -omics findings. Sci Rep.
2016 May 11;6:25619. doi: 10.1038/srep25619. PubMed PMID: 27167498; PubMed
Central PMCID: PMC4863247.

17: Carrick E, Vanmassenhove J, Glorieux G, Metzger J, Dakna M, Pejchinovski M,
Jankowski V, Mansoorian B, Husi H, Mullen W, Mischak H, Vanholder R, Van Biesen
W. Development of a MALDI MS-based platform for early detection of acute kidney
injury. Proteomics Clin Appl. 2016 Jul;10(7):732-42. doi: 10.1002/prca.201500117.
Epub 2016 May 17. PubMed PMID: 27119821; PubMed Central PMCID: PMC4950042.

18: Neisius U, Koeck T, Mischak H, Rossi SH, Olson E, Carty DM, Dymott JA,
Dominiczak AF, Berry C, Oldroyd KG, Delles C. Urine proteomics in the diagnosis
of stable angina. BMC Cardiovasc Disord. 2016 Apr 19;16:70. doi:
10.1186/s12872-016-0246-y. PubMed PMID: 27095611; PubMed Central PMCID:

19: Frantzi M, van Kessel KE, Zwarthoff EC, Marquez M, Rava M, Malats N,
Merseburger AS, Katafigiotis I, Stravodimos K, Mullen W, Zoidakis J, Makridakis
M, Pejchinovski M, Critselis E, Lichtinghagen R, Brand K, Dakna M, Roubelakis MG,
Theodorescu D, Vlahou A, Mischak H, Anagnou NP. Development and Validation of
Urine-based Peptide Biomarker Panels for Detecting Bladder Cancer in a
Multi-center Study. Clin Cancer Res. 2016 Aug 15;22(16):4077-86. doi:
10.1158/1078-0432.CCR-15-2715. Epub 2016 Mar 29. PubMed PMID: 27026199.

20: Lindhardt M, Persson F, Currie G, Pontillo C, Beige J, Delles C, von der
Leyen H, Mischak H, Navis G, Noutsou M, Ortiz A, Ruggenenti PL, Rychlik I,
Spasovski G, Rossing P. Proteomic prediction and Renin angiotensin aldosterone
system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic
patients with normoalbuminuria (PRIORITY): essential study design and rationale
of a randomised clinical multicentre trial. BMJ Open. 2016 Mar 2;6(3):e010310.
doi: 10.1136/bmjopen-2015-010310. PubMed PMID: 26936907; PubMed Central PMCID:

21: Pontillo C, Mischak H. Urinary biomarkers to predict CKD: is the future in
multi-marker panels? Nephrol Dial Transplant. 2016 Sep;31(9):1373-5. doi:
10.1093/ndt/gfv467. Epub 2016 Feb 29. Review. PubMed PMID: 26932685.

22: von Zur Mühlen C, Koeck T, Schiffer E, Sackmann C, Zürbig P, Hilgendorf I,
Reinöhl J, Rivera J, Zirlik A, Hehrlein C, Mischak H, Bode C, Peter K. Urine
proteome analysis as a discovery tool in patients with deep vein thrombosis and
pulmonary embolism. Proteomics Clin Appl. 2016 May;10(5):574-84. doi:
10.1002/prca.201500105. Epub 2016 Apr 4. PubMed PMID: 26898369.

23: Stepczynska A, Schanstra JP, Mischak H. Implementation of CE-MS-identified
proteome-based biomarker panels in drug development and patient management.
Bioanalysis. 2016;8(5):439-55. doi: 10.4155/bio.16.8. Epub 2016 Feb 19. PubMed
PMID: 26891752.

24: Klein J, Bascands JL, Mischak H, Schanstra JP. The role of urinary
peptidomics in kidney disease research. Kidney Int. 2016 Mar;89(3):539-45. doi:
10.1016/j.kint.2015.10.010. Epub 2016 Jan 14. PubMed PMID: 26880450.

25: Schönemeier B, Metzger J, Klein J, Husi H, Bremer B, Armbrecht N, Dakna M,
Schanstra JP, Rosendahl J, Wiegand J, Jäger M, Mullen W, Breuil B, Plentz RR,
Lichtinghagen R, Brand K, Kühnel F, Mischak H, Manns MP, Lankisch TO. Urinary
Peptide Analysis Differentiates Pancreatic Cancer From Chronic Pancreatitis.
Pancreas. 2016 Aug;45(7):1018-26. doi: 10.1097/MPA.0000000000000573. PubMed PMID:

26: Frantzi M, Latosinska A, Merseburger AS, Mischak H. Recent progress in
urinary proteome analysis for prostate cancer diagnosis and management. Expert
Rev Mol Diagn. 2015;15(12):1539-54. doi: 10.1586/14737159.2015.1104248. Epub 2015
Oct 22. Review. PubMed PMID: 26491818.

27: Cisek K, Krochmal M, Klein J, Mischak H. The application of multi-omics and
systems biology to identify therapeutic targets in chronic kidney disease.
Nephrol Dial Transplant. 2015 Oct 20. pii: gfv364. [Epub ahead of print] Review.
PubMed PMID: 26487673.

28: Seetho IW, Ramírez-Torres A, Albalat A, Mullen W, Mischak H, Parker RJ, Craig
S, Duffy N, Hardy KJ, Burniston JG, Wilding JP. Urinary proteomic profiling in
severe obesity and obstructive sleep apnoea with CPAP treatment. Sleep Sci. 2015
Apr-Jun;8(2):58-67. doi: 10.1016/j.slsci.2015.06.004. Epub 2015 Jul 17. PubMed
PMID: 26483946; PubMed Central PMCID: PMC4608901.

29: Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M,
Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H.
Identification of ageing-associated naturally occurring peptides in human urine.
Oncotarget. 2015 Oct 27;6(33):34106-17. doi: 10.18632/oncotarget.5896. PubMed
PMID: 26431327; PubMed Central PMCID: PMC4741439.

30: Latosinska A, Vougas K, Makridakis M, Klein J, Mullen W, Abbas M, Stravodimos
K, Katafigiotis I, Merseburger AS, Zoidakis J, Mischak H, Vlahou A, Jankowski V.
Comparative Analysis of Label-Free and 8-Plex iTRAQ Approach for Quantitative
Tissue Proteomic Analysis. PLoS One. 2015 Sep 2;10(9):e0137048. doi:
10.1371/journal.pone.0137048. eCollection 2015. Erratum in: PLoS One.
2015;10(10):e0139268. PubMed PMID: 26331617; PubMed Central PMCID: PMC4557910.

31: Pena MJ, de Zeeuw D, Mischak H, Jankowski J, Oberbauer R, Woloszczuk W,
Benner J, Dallmann G, Mayer B, Mayer G, Rossing P, Lambers Heerspink HJ.
Prognostic clinical and molecular biomarkers of renal disease in type 2 diabetes.
Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv86-95. doi: 10.1093/ndt/gfv252.
Review. PubMed PMID: 26209743.

32: Jankowski J, Schanstra JP, Mischak H. Body fluid peptide and protein
signatures in diabetic kidney diseases. Nephrol Dial Transplant. 2015 Aug;30
Suppl 4:iv43-53. doi: 10.1093/ndt/gfv091. Review. PubMed PMID: 26209737.

33: Filip S, Vougas K, Zoidakis J, Latosinska A, Mullen W, Spasovski G, Mischak
H, Vlahou A, Jankowski J. Comparison of Depletion Strategies for the Enrichment
of Low-Abundance Proteins in Urine. PLoS One. 2015 Jul 24;10(7):e0133773. doi:
10.1371/journal.pone.0133773. eCollection 2015. PubMed PMID: 26208298; PubMed
Central PMCID: PMC4514849.

34: Glorieux G, Mullen W, Duranton F, Filip S, Gayrard N, Husi H, Schepers E,
Neirynck N, Schanstra JP, Jankowski J, Mischak H, Argilés À, Vanholder R, Vlahou
A, Klein J. New insights in molecular mechanisms involved in chronic kidney
disease using high-resolution plasma proteome analysis. Nephrol Dial Transplant.
2015 Nov;30(11):1842-52. doi: 10.1093/ndt/gfv254. Epub 2015 Jul 9. PubMed PMID:

35: Zhang ZY, Thijs L, Petit T, Gu YM, Jacobs L, Yang WY, Liu YP, Koeck T, Zürbig
P, Jin Y, Verhamme P, Voigt JU, Kuznetsova T, Mischak H, Staessen JA. Urinary
Proteome and Systolic Blood Pressure as Predictors of 5-Year Cardiovascular and
Cardiac Outcomes in a General Population. Hypertension. 2015 Jul;66(1):52-60.
doi: 10.1161/HYPERTENSIONAHA.115.05296. Epub 2015 May 11. PubMed PMID: 26063667.

36: Frantzi M, Latosinska A, Flühe L, Hupe MC, Critselis E, Kramer MW,
Merseburger AS, Mischak H, Vlahou A. Developing proteomic biomarkers for bladder
cancer: towards clinical application. Nat Rev Urol. 2015 Jun;12(6):317-30. doi:
10.1038/nrurol.2015.100. Epub 2015 May 26. Review. PubMed PMID: 26032553.

37: Pejchinovski M, Klein J, Ramírez-Torres A, Bitsika V, Mermelekas G, Vlahou A,
Mullen W, Mischak H, Jankowski V. Comparison of higher energy collisional
dissociation and collision-induced dissociation MS/MS sequencing methods for
identification of naturally occurring peptides in human urine. Proteomics Clin
Appl. 2015 Jun;9(5-6):531-42. doi: 10.1002/prca.201400163. PubMed PMID: 25821083.

38: Mischak H. Pro: urine proteomics as a liquid kidney biopsy: no more kidney
punctures! Nephrol Dial Transplant. 2015 Apr;30(4):532-7. doi:
10.1093/ndt/gfv046. PubMed PMID: 25801638.

39: Mischak H. Opponent's comments. Nephrol Dial Transplant. 2015
Apr;30(4):531-2. doi: 10.1093/ndt/gfv044a. PubMed PMID: 25801637.

40: Mischak H, Critselis E, Hanash S, Gallagher WM, Vlahou A, Ioannidis JP.
Epidemiologic design and analysis for proteomic studies: a primer on -omic
technologies. Am J Epidemiol. 2015 May 1;181(9):635-47. doi: 10.1093/aje/kwu462.
Epub 2015 Mar 19. Review. PubMed PMID: 25792606.

41: Gleiss A, Dakna M, Mischak H, Heinze G. Two-group comparisons of
zero-inflated intensity values: the choice of test statistic matters.
Bioinformatics. 2015 Jul 15;31(14):2310-7. doi: 10.1093/bioinformatics/btv154.
Epub 2015 Mar 18. PubMed PMID: 25788623.

42: Brown CE, McCarthy NS, Hughes AD, Sever P, Stalmach A, Mullen W, Dominiczak
AF, Sattar N, Mischak H, Thom S, Mayet J, Stanton AV, Delles C. Urinary proteomic
biomarkers to predict cardiovascular events. Proteomics Clin Appl. 2015
Jun;9(5-6):610-7. doi: 10.1002/prca.201400195. Epub 2015 May 15. PubMed PMID:

43: Nally JE, Mullen W, Callanan JJ, Mischak H, Albalat A. Detection of urinary
biomarkers in reservoir hosts of leptospirosis by capillary electrophoresis-mass
spectrometry. Proteomics Clin Appl. 2015 Jun;9(5-6):543-51. doi:
10.1002/prca.201400205. Epub 2015 Apr 17. PubMed PMID: 25736478.

44: Mischak H, Delles C, Vlahou A, Vanholder R. Proteomic biomarkers in kidney
disease: issues in development and implementation. Nat Rev Nephrol. 2015
Apr;11(4):221-32. doi: 10.1038/nrneph.2014.247. Epub 2015 Feb 3. Review. PubMed
PMID: 25643662.

45: Pontillo C, Filip S, Borràs DM, Mullen W, Vlahou A, Mischak H. CE-MS-based
proteomics in biomarker discovery and clinical application. Proteomics Clin Appl.
2015 Apr;9(3-4):322-34. doi: 10.1002/prca.201400115. Epub 2015 Mar 24. Review.
PubMed PMID: 25641774.

46: Pejchinovski M, Hrnjez D, Ramirez-Torres A, Bitsika V, Mermelekas G, Vlahou
A, Zürbig P, Mischak H, Metzger J, Koeck T. Capillary zone electrophoresis
on-line coupled to mass spectrometry: A perspective application for clinical
proteomics. Proteomics Clin Appl. 2015 Jun;9(5-6):453-68. doi:
10.1002/prca.201400113. Epub 2015 Apr 7. Review. PubMed PMID: 25641766.

47: Schanstra JP, Zürbig P, Alkhalaf A, Argiles A, Bakker SJ, Beige J, Bilo HJ,
Chatzikyrkou C, Dakna M, Dawson J, Delles C, Haller H, Haubitz M, Husi H,
Jankowski J, Jerums G, Kleefstra N, Kuznetsova T, Maahs DM, Menne J, Mullen W,
Ortiz A, Persson F, Rossing P, Ruggenenti P, Rychlik I, Serra AL, Siwy J,
Snell-Bergeon J, Spasovski G, Staessen JA, Vlahou A, Mischak H, Vanholder R.
Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides. J
Am Soc Nephrol. 2015 Aug;26(8):1999-2010. doi: 10.1681/ASN.2014050423. Epub 2015
Jan 14. PubMed PMID: 25589610; PubMed Central PMCID: PMC4520165.

48: Bhat A, Heinzel A, Mayer B, Perco P, Mühlberger I, Husi H, Merseburger AS,
Zoidakis J, Vlahou A, Schanstra JP, Mischak H, Jankowski V. Protein interactome
of muscle invasive bladder cancer. PLoS One. 2015 Jan 8;10(1):e0116404. doi:
10.1371/journal.pone.0116404. eCollection 2015. PubMed PMID: 25569276; PubMed
Central PMCID: PMC4287622.

49: Silva S, Bronze MR, Figueira ME, Siwy J, Mischak H, Combet E, Mullen W.
Impact of a 6-wk olive oil supplementation in healthy adults on urinary proteomic
biomarkers of coronary artery disease, chronic kidney disease, and diabetes
(types 1 and 2): a randomized, parallel, controlled, double-blind study. Am J
Clin Nutr. 2015 Jan;101(1):44-54. doi: 10.3945/ajcn.114.094219. Epub 2014 Nov 19.
Erratum in: Am J Clin Nutr. 2015 May;101(5):1105. Siwy, Justina [corrected to
Siwy, Justyna]. PubMed PMID: 25527749.

50: Filip S, Zoidakis J, Vlahou A, Mischak H. Advances in urinary proteome
analysis and applications in systems biology. Bioanalysis. 2014;6(19):2549-69.
doi: 10.4155/bio.14.210. Review. PubMed PMID: 25411698.

51: Bhat A, Dakna M, Mischak H. Integrating proteomics profiling data sets: a
network perspective. Methods Mol Biol. 2015;1243:237-53. doi:
10.1007/978-1-4939-1872-0_14. Review. PubMed PMID: 25384750.

52: Stalmach A, Husi H, Mosbahi K, Albalat A, Mullen W, Mischak H. Methods in
capillary electrophoresis coupled to mass spectrometry for the identification of
clinical proteomic/peptidomic biomarkers in biofluids. Methods Mol Biol.
2015;1243:187-205. doi: 10.1007/978-1-4939-1872-0_11. PubMed PMID: 25384747.

53: Seetho IW, Siwy J, Albalat A, Mullen W, Mischak H, Parker RJ, Craig S, Duffy
N, Hardy KJ, Burniston JG, Wilding JP. Urinary proteomics in obstructive sleep
apnoea and obesity. Eur J Clin Invest. 2014 Nov;44(11):1104-15. doi:
10.1111/eci.12346. PubMed PMID: 25267120.

54: Nkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P,
Schumacher B. Proteome analysis in the assessment of ageing. Ageing Res Rev. 2014
Nov;18:74-85. doi: 10.1016/j.arr.2014.09.002. Epub 2014 Sep 22. Review. PubMed
PMID: 25257180.

55: Stalmach A, Johnsson H, McInnes IB, Husi H, Klein J, Dakna M, Mullen W,
Mischak H, Porter D. Identification of urinary peptide biomarkers associated with
rheumatoid arthritis. PLoS One. 2014 Aug 21;9(8):e104625. doi:
10.1371/journal.pone.0104625. eCollection 2014. PubMed PMID: 25144639; PubMed
Central PMCID: PMC4140712.

56: Zhang Z, Staessen JA, Thijs L, Gu Y, Liu Y, Jacobs L, Koeck T, Zürbig P,
Mischak H, Kuznetsova T. Left ventricular diastolic function in relation to the
urinary proteome: a proof-of-concept study in a general population. Int J
Cardiol. 2014 Sep;176(1):158-65. doi: 10.1016/j.ijcard.2014.07.014. Epub 2014 Jul
12. PubMed PMID: 25065337; PubMed Central PMCID: PMC4155932.

57: Gu YM, Thijs L, Liu YP, Zhang Z, Jacobs L, Koeck T, Zürbig P, Lichtinghagen
R, Brand K, Kuznetsova T, Olivi L, Verhamme P, Delles C, Mischak H, Staessen JA.
The urinary proteome as correlate and predictor of renal function in a population
study. Nephrol Dial Transplant. 2014 Dec;29(12):2260-8. doi: 10.1093/ndt/gfu234.
Epub 2014 Jun 30. PubMed PMID: 24981581.

58: Filip S, Pontillo C, Peter Schanstra J, Vlahou A, Mischak H, Klein J. Urinary
proteomics and molecular determinants of chronic kidney disease: possible link to
proteases. Expert Rev Proteomics. 2014 Oct;11(5):535-48. doi:
10.1586/14789450.2014.926224. Epub 2014 Jun 24. Review. PubMed PMID: 24957818.

59: Koss MJ, Hoffmann J, Nguyen N, Pfister M, Mischak H, Mullen W, Husi H, Rejdak
R, Koch F, Jankowski J, Krueger K, Bertelmann T, Klein J, Schanstra JP, Siwy J.
Proteomics of vitreous humor of patients with exudative age-related macular
degeneration. PLoS One. 2014 May 14;9(5):e96895. doi:
10.1371/journal.pone.0096895. eCollection 2014. PubMed PMID: 24828575; PubMed
Central PMCID: PMC4020801.

60: Nkuipou-Kenfack E, Duranton F, Gayrard N, Argilés À, Lundin U, Weinberger KM,
Dakna M, Delles C, Mullen W, Husi H, Klein J, Koeck T, Zürbig P, Mischak H.
Assessment of metabolomic and proteomic biomarkers in detection and prognosis of
progression of renal function in chronic kidney disease. PLoS One. 2014 May
9;9(5):e96955. doi: 10.1371/journal.pone.0096955. eCollection 2014. PubMed PMID:
24817014; PubMed Central PMCID: PMC4016198.

61: Mullen W, Saigusa D, Abe T, Adamski J, Mischak H. Proteomics and metabolomics
as tools to unravel novel culprits and mechanisms of uremic toxicity: instrument
or hype? Semin Nephrol. 2014 Mar;34(2):180-90. doi:
10.1016/j.semnephrol.2014.02.009. Epub 2014 Feb 18. Review. PubMed PMID:

62: Schanstra JP, Mischak H. Proteomic urinary biomarker approach in renal
disease: from discovery to implementation. Pediatr Nephrol. 2015
May;30(5):713-25. doi: 10.1007/s00467-014-2790-y. Epub 2014 Mar 15. Review.
PubMed PMID: 24633400.

63: Siwy J, Schanstra JP, Argiles A, Bakker SJ, Beige J, Boucek P, Brand K,
Delles C, Duranton F, Fernandez-Fernandez B, Jankowski ML, Al Khatib M, Kunt T,
Lajer M, Lichtinghagen R, Lindhardt M, Maahs DM, Mischak H, Mullen W, Navis G,
Noutsou M, Ortiz A, Persson F, Petrie JR, Roob JM, Rossing P, Ruggenenti P,
Rychlik I, Serra AL, Snell-Bergeon J, Spasovski G, Stojceva-Taneva O, Trillini M,
von der Leyen H, Winklhofer-Roob BM, Zürbig P, Jankowski J. Multicentre
prospective validation of a urinary peptidome-based classifier for the diagnosis
of type 2 diabetic nephropathy. Nephrol Dial Transplant. 2014 Aug;29(8):1563-70.
doi: 10.1093/ndt/gfu039. Epub 2014 Mar 2. PubMed PMID: 24589724; PubMed Central
PMCID: PMC4118140.

64: Husi H, Van Agtmael T, Mullen W, Bahlmann FH, Schanstra JP, Vlahou A, Delles
C, Perco P, Mischak H. Proteome-based systems biology analysis of the diabetic
mouse aorta reveals major changes in fatty acid biosynthesis as potential
hallmark in diabetes mellitus-associated vascular disease. Circ Cardiovasc Genet.
2014 Apr;7(2):161-70. doi: 10.1161/CIRCGENETICS.113.000196. Epub 2014 Feb 26.
PubMed PMID: 24573165.

65: Mischak H, Vlahou A, Righetti PG, Calvete JJ. Putting value in biomarker
research and reporting. J Proteomics. 2014 Jan 16;96:A1-3. doi:
10.1016/j.jprot.2013.12.002. PubMed PMID: 24461424.

66: Albalat A, Husi H, Stalmach A, Schanstra JP, Mischak H. Classical MALDI-MS
versus CE-based ESI-MS proteomic profiling in urine for clinical applications.
Bioanalysis. 2014 Jan;6(2):247-66. doi: 10.4155/bio.13.313. Review. PubMed PMID:

67: Klein J, Buffin-Meyer B, Mullen W, Carty DM, Delles C, Vlahou A, Mischak H,
Decramer S, Bascands JL, Schanstra JP. Clinical proteomics in obstetrics and
neonatology. Expert Rev Proteomics. 2014 Feb;11(1):75-89. doi:
10.1586/14789450.2014.872564. Epub 2014 Jan 3. Review. PubMed PMID: 24404900.

68: Frantzi M, Metzger J, Banks RE, Husi H, Klein J, Dakna M, Mullen W, Cartledge
JJ, Schanstra JP, Brand K, Kuczyk MA, Mischak H, Vlahou A, Theodorescu D,
Merseburger AS. Discovery and validation of urinary biomarkers for detection of
renal cell carcinoma. J Proteomics. 2014 Feb 26;98:44-58. doi:
10.1016/j.jprot.2013.12.010. Epub 2013 Dec 25. PubMed PMID: 24374379.

69: Klein J, Papadopoulos T, Mischak H, Mullen W. Comparison of CE-MS/MS and
LC-MS/MS sequencing demonstrates significant complementarity in natural peptide
identification in human urine. Electrophoresis. 2014 Apr;35(7):1060-4. doi:
10.1002/elps.201300327. Epub 2013 Nov 20. PubMed PMID: 24254231.

70: Duranton F, Lundin U, Gayrard N, Mischak H, Aparicio M, Mourad G, Daurès JP,
Weinberger KM, Argilés A. Plasma and urinary amino acid metabolomic profiling in
patients with different levels of kidney function. Clin J Am Soc Nephrol. 2014
Jan;9(1):37-45. doi: 10.2215/CJN.06000613. Epub 2013 Nov 14. PubMed PMID:
24235289; PubMed Central PMCID: PMC3878706.

71: Husi H, Sanchez-Niño MD, Delles C, Mullen W, Vlahou A, Ortiz A, Mischak H. A
combinatorial approach of Proteomics and Systems Biology in unravelling the
mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in
murine AKI. BMC Syst Biol. 2013 Oct 30;7:110. doi: 10.1186/1752-0509-7-110.
PubMed PMID: 24172336; PubMed Central PMCID: PMC3827826.

72: Dissard R, Klein J, Caubet C, Breuil B, Siwy J, Hoffman J, Sicard L, Ducassé
L, Rascalou S, Payre B, Buléon M, Mullen W, Mischak H, Tack I, Bascands JL,
Buffin-Meyer B, Schanstra JP. Long term metabolic syndrome induced by a high fat
high fructose diet leads to minimal renal injury in C57BL/6 mice. PLoS One. 2013
Oct 3;8(10):e76703. doi: 10.1371/journal.pone.0076703. eCollection 2013. PubMed
PMID: 24098551; PubMed Central PMCID: PMC3789664.

73: Latosinska A, Frantzi M, Vlahou A, Mischak H. Clinical applications of
capillary electrophoresis coupled to mass spectrometry in biomarker discovery:
Focus on Bladder Cancer. Proteomics Clin Appl. 2013 Dec;7(11-12):779-93. doi:
10.1002/prca.201300038. Review. PubMed PMID: 23970371.

74: Klein J, Lacroix C, Caubet C, Siwy J, Zürbig P, Dakna M, Muller F, Breuil B,
Stalmach A, Mullen W, Mischak H, Bandin F, Monsarrat B, Bascands JL, Decramer S,
Schanstra JP. Fetal urinary peptides to predict postnatal outcome of renal
disease in fetuses with posterior urethral valves (PUV). Sci Transl Med. 2013 Aug
14;5(198):198ra106. doi: 10.1126/scitranslmed.3005807. PubMed PMID: 23946195.

75: Albalat A, Stalmach A, Bitsika V, Siwy J, Schanstra JP, Petropoulos AD,
Vlahou A, Jankowski J, Persson F, Rossing P, Jaskolla TW, Mischak H, Husi H.
Improving peptide relative quantification in MALDI-TOF MS for biomarker
assessment. Proteomics. 2013 Oct;13(20):2967-75. doi: 10.1002/pmic.201300100.
PubMed PMID: 23943474.

76: Frantzi M, Zoidakis J, Papadopoulos T, Zürbig P, Katafigiotis I, Stravodimos
K, Lazaris A, Giannopoulou I, Ploumidis A, Mischak H, Mullen W, Vlahou A. IMAC
fractionation in combination with LC-MS reveals H2B and NIF-1 peptides as
potential bladder cancer biomarkers. J Proteome Res. 2013 Sep 6;12(9):3969-79.
doi: 10.1021/pr400255h. Epub 2013 Aug 21. PubMed PMID: 23924207.

77: Weissinger EM, Metzger J, Dobbelstein C, Wolff D, Schleuning M, Kuzmina Z,
Greinix H, Dickinson AM, Mullen W, Kreipe H, Hamwi I, Morgan M, Krons A,
Tchebotarenko I, Ihlenburg-Schwarz D, Dammann E, Collin M, Ehrlich S, Diedrich H,
Stadler M, Eder M, Holler E, Mischak H, Krauter J, Ganser A. Proteomic peptide
profiling for preemptive diagnosis of acute graft-versus-host disease after
allogeneic stem cell transplantation. Leukemia. 2014 Apr;28(4):842-52. doi:
10.1038/leu.2013.210. Epub 2013 Jul 11. PubMed PMID: 23842427.

78: Klein G, Schanstra JP, Hoffmann J, Mischak H, Siwy J, Zimmermann K.
Proteomics as a Quality Control Tool of Pharmaceutical Probiotic Bacterial Lysate
Products. PLoS One. 2013 Jun 19;8(6):e66682. doi: 10.1371/journal.pone.0066682.
Print 2013. PubMed PMID: 23840518; PubMed Central PMCID: PMC3686750.

79: Rodríguez-Suárez E, Siwy J, Zürbig P, Mischak H. Urine as a source for
clinical proteome analysis: from discovery to clinical application. Biochim
Biophys Acta. 2014 May;1844(5):884-98. doi: 10.1016/j.bbapap.2013.06.016. Epub
2013 Jul 2. Review. PubMed PMID: 23831154.

80: Argilés Á, Siwy J, Duranton F, Gayrard N, Dakna M, Lundin U, Osaba L, Delles
C, Mourad G, Weinberger KM, Mischak H. CKD273, a new proteomics classifier
assessing CKD and its prognosis. PLoS One. 2013 May 14;8(5):e62837. doi:
10.1371/journal.pone.0062837. Print 2013. PubMed PMID: 23690958; PubMed Central
PMCID: PMC3653906.

81: Mansor R, Mullen W, Albalat A, Zerefos P, Mischak H, Barrett DC, Biggs A,
Eckersall PD. A peptidomic approach to biomarker discovery for bovine mastitis. J
Proteomics. 2013 Jun 24;85:89-98. doi: 10.1016/j.jprot.2013.04.027. Epub 2013 Apr
30. PubMed PMID: 23639846.

82: Jankowski V, Schulz A, Kretschmer A, Mischak H, Boehringer F, van der Giet M,
Janke D, Schuchardt M, Herwig R, Zidek W, Jankowski J. The enzymatic activity of
the VEGFR2 receptor for the biosynthesis of dinucleoside polyphosphates. J Mol
Med (Berl). 2013 Sep;91(9):1095-107. doi: 10.1007/s00109-013-1036-y. Epub 2013
May 1. PubMed PMID: 23636508.

83: Stalmach A, Albalat A, Mullen W, Mischak H. Recent advances in capillary
electrophoresis coupled to mass spectrometry for clinical proteomic applications.
Electrophoresis. 2013 Jun;34(11):1452-64. doi: 10.1002/elps.201200708. Epub 2013
May 8. Review. PubMed PMID: 23512263.

84: Klein J, Eales J, Zürbig P, Vlahou A, Mischak H, Stevens R. Proteasix: a tool
for automated and large-scale prediction of proteases involved in naturally
occurring peptide generation. Proteomics. 2013 Apr;13(7):1077-82. doi:
10.1002/pmic.201200493. Epub 2013 Feb 26. PubMed PMID: 23348921.

85: Kistler AD, Serra AL, Siwy J, Poster D, Krauer F, Torres VE, Mrug M, Grantham
JJ, Bae KT, Bost JE, Mullen W, Wüthrich RP, Mischak H, Chapman AB. Urinary
proteomic biomarkers for diagnosis and risk stratification of autosomal dominant
polycystic kidney disease: a multicentric study. PLoS One. 2013;8(1):e53016. doi:
10.1371/journal.pone.0053016. Epub 2013 Jan 10. Erratum in: PLoS One. 2013;8(8).
doi:10.1371/annotation/9281c713-d253-4a1a-8255-92e691e77a24. PubMed PMID:
23326375; PubMed Central PMCID: PMC3542378.

86: Siwy J, Zoja C, Klein J, Benigni A, Mullen W, Mayer B, Mischak H, Jankowski
J, Stevens R, Vlahou A, Kossida S, Perco P, Bahlmann FH. Evaluation of the Zucker
diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic
profiles. PLoS One. 2012;7(12):e51334. doi: 10.1371/journal.pone.0051334. Epub
2012 Dec 7. PubMed PMID: 23236474; PubMed Central PMCID: PMC3517416.

87: Roscioni SS, de Zeeuw D, Hellemons ME, Mischak H, Zürbig P, Bakker SJ,
Gansevoort RT, Reinhard H, Persson F, Lajer M, Rossing P, Lambers Heerspink HJ. A
urinary peptide biomarker set predicts worsening of albuminuria in type 2
diabetes mellitus. Diabetologia. 2013 Feb;56(2):259-67. doi:
10.1007/s00125-012-2755-2. Epub 2012 Oct 20. PubMed PMID: 23086559.

88: Mischak H, Vlahou A, Ioannidis JP. Technical aspects and inter-laboratory
variability in native peptide profiling: the CE-MS experience. Clin Biochem. 2013
Apr;46(6):432-43. doi: 10.1016/j.clinbiochem.2012.09.025. Epub 2012 Oct 4.
Review. PubMed PMID: 23041249.

89: Albalat A, Franke J, Gonzalez J, Mischak H, Zürbig P. Urinary proteomics
based on capillary electrophoresis coupled to mass spectrometry in kidney
disease. Methods Mol Biol. 2013;919:203-13. doi: 10.1007/978-1-62703-029-8_19.
PubMed PMID: 22976103.

90: Herget-Rosenthal S, Metzger J, Albalat A, Bitsika V, Mischak H. Proteomic
biomarkers for the early detection of acute kidney injury. Prilozi.
2012;33(1):27-48. Review. PubMed PMID: 22952093.

91: Zürbig P, Jerums G, Hovind P, Macisaac RJ, Mischak H, Nielsen SE,
Panagiotopoulos S, Persson F, Rossing P. Urinary proteomics for early diagnosis
in diabetic nephropathy. Diabetes. 2012 Dec;61(12):3304-13. doi:
10.2337/db12-0348. Epub 2012 Aug 7. PubMed PMID: 22872235; PubMed Central PMCID:

92: Molin L, Seraglia R, Lapolla A, Ragazzi E, Gonzalez J, Vlahou A, Schanstra
JP, Albalat A, Dakna M, Siwy J, Jankowski J, Bitsika V, Mischak H, Zürbig P,
Traldi P. A comparison between MALDI-MS and CE-MS data for biomarker assessment
in chronic kidney diseases. J Proteomics. 2012 Oct 22;75(18):5888-97. doi:
10.1016/j.jprot.2012.07.024. Epub 2012 Jul 26. PubMed PMID: 22842158.

93: Mischak H. How to get proteomics to the clinic? Issues in clinical
proteomics, exemplified by CE-MS. Proteomics Clin Appl. 2012 Oct;6(9-10):437-42.
doi: 10.1002/prca.201200027. Epub 2012 Sep 24. PubMed PMID: 22821927.

94: Kuznetsova T, Mischak H, Mullen W, Staessen JA. Urinary proteome analysis in
hypertensive patients with left ventricular diastolic dysfunction. Eur Heart J.
2012 Sep;33(18):2342-50. doi: 10.1093/eurheartj/ehs185. Epub 2012 Jul 11. PubMed
PMID: 22789915; PubMed Central PMCID: PMC3705161.

95: Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R,
Argiles A; European Uremic Toxin Work Group. Normal and pathologic concentrations
of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi:
10.1681/ASN.2011121175. Epub 2012 May 24. Review. Erratum in: J Am Soc Nephrol.
2013 Dec;24(12):2127-9. PubMed PMID: 22626821; PubMed Central PMCID: PMC3380651.

96: Dawson J, Walters M, Delles C, Mischak H, Mullen W. Urinary proteomics to
support diagnosis of stroke. PLoS One. 2012;7(5):e35879. doi:
10.1371/journal.pone.0035879. Epub 2012 May 16. PubMed PMID: 22615742; PubMed
Central PMCID: PMC3353991.

97: Metzger J, Negm AA, Plentz RR, Weismüller TJ, Wedemeyer J, Karlsen TH, Dakna
M, Mullen W, Mischak H, Manns MP, Lankisch TO. Urine proteomic analysis
differentiates cholangiocarcinoma from primary sclerosing cholangitis and other
benign biliary disorders. Gut. 2013 Jan;62(1):122-30. doi:
10.1136/gutjnl-2012-302047. Epub 2012 May 12. PubMed PMID: 22580416.

98: Mischak H, Ioannidis JP, Argiles A, Attwood TK, Bongcam-Rudloff E, Broenstrup
M, Charonis A, Chrousos GP, Delles C, Dominiczak A, Dylag T, Ehrich J, Egido J,
Findeisen P, Jankowski J, Johnson RW, Julien BA, Lankisch T, Leung HY, Maahs D,
Magni F, Manns MP, Manolis E, Mayer G, Navis G, Novak J, Ortiz A, Persson F,
Peter K, Riese HH, Rossing P, Sattar N, Spasovski G, Thongboonkerd V, Vanholder
R, Schanstra JP, Vlahou A. Implementation of proteomic biomarkers: making it
work. Eur J Clin Invest. 2012 Sep;42(9):1027-36. doi:
10.1111/j.1365-2362.2012.02674.x. Epub 2012 Apr 21. PubMed PMID: 22519700; PubMed
Central PMCID: PMC3464367.

99: Rouse R, Siwy J, Mullen W, Mischak H, Metzger J, Hanig J. Proteomic candidate
biomarkers of drug-induced nephrotoxicity in the rat. PLoS One. 2012;7(4):e34606.
doi: 10.1371/journal.pone.0034606. Epub 2012 Apr 11. PubMed PMID: 22509332;
PubMed Central PMCID: PMC3324487.

100: Mullen W, Albalat A, Gonzalez J, Zerefos P, Siwy J, Franke J, Mischak H.
Performance of different separation methods interfaced in the same MS-reflection
TOF detector: a comparison of performance between CE versus HPLC for biomarker
analysis. Electrophoresis. 2012 Feb;33(4):567-74. doi: 10.1002/elps.201100415.
PubMed PMID: 22451049.

101: von zur Muhlen C, Schiffer E, Sackmann C, Zürbig P, Neudorfer I, Zirlik A,
Htun N, Iphöfer A, Jänsch L, Mischak H, Bode C, Chen YC, Peter K. Urine proteome
analysis reflects atherosclerotic disease in an ApoE-/- mouse model and allows
the discovery of new candidate biomarkers in mouse and human atherosclerosis. Mol
Cell Proteomics. 2012 Jul;11(7):M111.013847. doi: 10.1074/mcp.M111.013847. Epub
2012 Feb 27. PubMed PMID: 22371488; PubMed Central PMCID: PMC3394942.

102: Drube J, Schiffer E, Lau E, Petersen C, Kirschstein M, Kemper MJ,
Lichtinghagen R, Ure B, Mischak H, Pape L, Ehrich JH. Urinary proteome analysis
to exclude severe vesicoureteral reflux. Pediatrics. 2012 Feb;129(2):e356-63.
doi: 10.1542/peds.2010-3467. Epub 2012 Jan 23. PubMed PMID: 22271698.

103: Bandin F, Siwy J, Breuil B, Mischak H, Bascands JL, Decramer S, Schanstra
JP. Urinary proteome analysis at 5-year followup of patients with nonoperated
ureteropelvic junction obstruction suggests ongoing kidney remodeling. J Urol.
2012 Mar;187(3):1006-11. doi: 10.1016/j.juro.2011.10.169. Epub 2012 Jan 20.
PubMed PMID: 22264461.

104: Mullen W, Gonzalez J, Siwy J, Franke J, Sattar N, Mullan A, Roberts S,
Delles C, Mischak H, Albalat A. A pilot study on the effect of short-term
consumption of a polyphenol rich drink on biomarkers of coronary artery disease
defined by urinary proteomics. J Agric Food Chem. 2011 Dec 28;59(24):12850-7.
doi: 10.1021/jf203369r. Epub 2011 Nov 28. PubMed PMID: 22070129.

105: Jahn H, Wittke S, Zürbig P, Raedler TJ, Arlt S, Kellmann M, Mullen W,
Eichenlaub M, Mischak H, Wiedemann K. Peptide fingerprinting of Alzheimer's
disease in cerebrospinal fluid: identification and prospective evaluation of new
synaptic biomarkers. PLoS One. 2011;6(10):e26540. doi:
10.1371/journal.pone.0026540. Epub 2011 Oct 26. PubMed PMID: 22046305; PubMed
Central PMCID: PMC3202544.

106: Albalat A, Mischak H, Mullen W. Clinical application of urinary
proteomics/peptidomics. Expert Rev Proteomics. 2011 Oct;8(5):615-29. doi:
10.1586/epr.11.46. Review. PubMed PMID: 21999832.

107: Mullen W, Delles C, Mischak H; EuroKUP COST action. Urinary proteomics in
the assessment of chronic kidney disease. Curr Opin Nephrol Hypertens. 2011
Nov;20(6):654-61. doi: 10.1097/MNH.0b013e32834b7ffa. Review. PubMed PMID:

108: Albalat A, Mischak H, Mullen W. Urine proteomics in clinical applications:
technologies, principal considerations and clinical implementation. Prilozi.
2011;32(1):13-44. Review. PubMed PMID: 21822176.

109: Kistler AD, Siwy J, Breunig F, Jeevaratnam P, Scherl A, Mullen W, Warnock
DG, Wanner C, Hughes DA, Mischak H, Wüthrich RP, Serra AL. A distinct urinary
biomarker pattern characteristic of female Fabry patients that mirrors response
to enzyme replacement therapy. PLoS One. 2011;6(6):e20534. doi:
10.1371/journal.pone.0020534. Epub 2011 Jun 15. PubMed PMID: 21698285; PubMed
Central PMCID: PMC3115947.

110: Mischak H, Thongboonkerd V, Schanstra JP, Vlahou A. Renal and urinary
proteomics. Proteomics Clin Appl. 2011 Jun;5(5-6):211-3. doi:
10.1002/prca.201190031. PubMed PMID: 21618704.

111: Metzger J, Chatzikyrkou C, Broecker V, Schiffer E, Jaensch L, Iphoefer A,
Mengel M, Mullen W, Mischak H, Haller H, Gwinner W. Diagnosis of subclinical and
clinical acute T-cell-mediated rejection in renal transplant patients by urinary
proteome analysis. Proteomics Clin Appl. 2011 Jun;5(5-6):322-33. doi:
10.1002/prca.201000153. Epub 2011 Apr 29. PubMed PMID: 21538920.

112: Lankisch TO, Metzger J, Negm AA, Vosskuhl K, Schiffer E, Siwy J, Weismüller
TJ, Schneider AS, Thedieck K, Baumeister R, Zürbig P, Weissinger EM, Manns MP,
Mischak H, Wedemeyer J. Bile proteomic profiles differentiate cholangiocarcinoma
from primary sclerosing cholangitis and choledocholithiasis. Hepatology. 2011
Mar;53(3):875-84. doi: 10.1002/hep.24103. Epub 2011 Jan 3. PubMed PMID: 21374660.

113: Mayer G, Heinze G, Mischak H, Hellemons ME, Heerspink HJ, Bakker SJ, de
Zeeuw D, Haiduk M, Rossing P, Oberbauer R. Omics-bioinformatics in the context of
clinical data. Methods Mol Biol. 2011;719:479-97. doi:
10.1007/978-1-61779-027-0_22. PubMed PMID: 21370098.

114: Foucher C, Schiffer E, Mischak H, Ansquer JC, Wilbraham D. Effect of
fenofibrate treatment on the low molecular weight urinary proteome of healthy
volunteers. Proteomics Clin Appl. 2011 Apr;5(3-4):159-66. doi:
10.1002/prca.201000076. Epub 2011 Feb 24. PubMed PMID: 21360683.

115: Schiffer E, Liabeuf S, Lacroix C, Temmar M, Renard C, Monsarrat B, Choukroun
G, Lemke HD, Vanholder R, Mischak H, Massy ZA; European Uremic Toxin Work Group
(EUTox). Markers of vascular disease in plasma from patients with chronic kidney
disease identified by proteomic analysis. J Hypertens. 2011 Apr;29(4):783-90.
doi: 10.1097/HJH.0b013e3283441129. PubMed PMID: 21358419.

116: Mischak H, Schanstra JP. CE-MS in biomarker discovery, validation, and
clinical application. Proteomics Clin Appl. 2011 Feb;5(1-2):9-23. doi:
10.1002/prca.201000058. Epub 2010 Nov 11. Review. PubMed PMID: 21280234.

117: Dakna M, Harris K, Kalousis A, Carpentier S, Kolch W, Schanstra JP, Haubitz
M, Vlahou A, Mischak H, Girolami M. Addressing the challenge of defining valid
proteomic biomarkers and classifiers. BMC Bioinformatics. 2010 Dec 10;11:594.
doi: 10.1186/1471-2105-11-594. PubMed PMID: 21208396; PubMed Central PMCID:

118: Carty DM, Siwy J, Brennand JE, Zürbig P, Mullen W, Franke J, McCulloch JW,
Roberts CT, North RA, Chappell LC, Mischak H, Poston L, Dominiczak AF, Delles C.
Urinary proteomics for prediction of preeclampsia. Hypertension. 2011
Mar;57(3):561-9. doi: 10.1161/HYPERTENSIONAHA.110.164285. Epub 2011 Jan 3.
Erratum in: Hypertension. 2011 Oct;58(4):e32. Roberts, Claire T [added]. PubMed
PMID: 21199994.

119: Mischak H, Kolch W, Aivaliotis M, Bouyssié D, Court M, Dihazi H, Dihazi GH,
Franke J, Garin J, Gonzalez de Peredo A, Iphöfer A, Jänsch L, Lacroix C,
Makridakis M, Masselon C, Metzger J, Monsarrat B, Mrug M, Norling M, Novak J,
Pich A, Pitt A, Bongcam-Rudloff E, Siwy J, Suzuki H, Thongboonkerd V, Wang LS,
Zoidakis J, Zürbig P, Schanstra JP, Vlahou A. Comprehensive human urine standards
for comparability and standardization in clinical proteome analysis. Proteomics
Clin Appl. 2010 Apr;4(4):464-78. doi: 10.1002/prca.200900189. Epub 2010 Feb 3.
PubMed PMID: 21137064; PubMed Central PMCID: PMC3064949.

120: Mischak H, Delles C, Klein J, Schanstra JP. Urinary proteomics based on
capillary electrophoresis-coupled mass spectrometry in kidney disease: discovery
and validation of biomarkers, and clinical application. Adv Chronic Kidney Dis.
2010 Nov;17(6):493-506. doi: 10.1053/j.ackd.2010.09.004. Review. PubMed PMID:

121: Andersen S, Mischak H, Zürbig P, Parving HH, Rossing P. Urinary proteome
analysis enables assessment of renoprotective treatment in type 2 diabetic
patients with microalbuminuria. BMC Nephrol. 2010 Nov 1;11:29. doi:
10.1186/1471-2369-11-29. PubMed PMID: 21040538; PubMed Central PMCID: PMC2988775.

122: Alkhalaf A, Zürbig P, Bakker SJ, Bilo HJ, Cerna M, Fischer C, Fuchs S,
Janssen B, Medek K, Mischak H, Roob JM, Rossing K, Rossing P, Rychlík I, Sourij
H, Tiran B, Winklhofer-Roob BM, Navis GJ; PREDICTIONS Group. Multicentric
validation of proteomic biomarkers in urine specific for diabetic nephropathy.
PLoS One. 2010 Oct 20;5(10):e13421. doi: 10.1371/journal.pone.0013421. PubMed
PMID: 20975990; PubMed Central PMCID: PMC2958112.

123: Maahs DM, Siwy J, Argilés A, Cerna M, Delles C, Dominiczak AF, Gayrard N,
Iphöfer A, Jänsch L, Jerums G, Medek K, Mischak H, Navis GJ, Roob JM, Rossing K,
Rossing P, Rychlík I, Schiffer E, Schmieder RE, Wascher TC, Winklhofer-Roob BM,
Zimmerli LU, Zürbig P, Snell-Bergeon JK. Urinary collagen fragments are
significantly altered in diabetes: a link to pathophysiology. PLoS One. 2010 Sep
28;5(9). pii: e13051. doi: 10.1371/journal.pone.0013051. PubMed PMID: 20927192;
PubMed Central PMCID: PMC2946909.

124: Metzger J, Kirsch T, Schiffer E, Ulger P, Mentes E, Brand K, Weissinger EM,
Haubitz M, Mischak H, Herget-Rosenthal S. Urinary excretion of twenty peptides
forms an early and accurate diagnostic pattern of acute kidney injury. Kidney
Int. 2010 Dec;78(12):1252-62. doi: 10.1038/ki.2010.322. Epub 2010 Sep 8. PubMed
PMID: 20827258.

125: Delles C, Schiffer E, von Zur Muhlen C, Peter K, Rossing P, Parving HH,
Dymott JA, Neisius U, Zimmerli LU, Snell-Bergeon JK, Maahs DM, Schmieder RE,
Mischak H, Dominiczak AF. Urinary proteomic diagnosis of coronary artery disease:
identification and clinical validation in 623 individuals. J Hypertens. 2010
Nov;28(11):2316-22. doi: 10.1097/HJH.0b013e32833d81b7. PubMed PMID: 20811296.

126: Mischak H, Allmaier G, Apweiler R, Attwood T, Baumann M, Benigni A, Bennett
SE, Bischoff R, Bongcam-Rudloff E, Capasso G, Coon JJ, D'Haese P, Dominiczak AF,
Dakna M, Dihazi H, Ehrich JH, Fernandez-Llama P, Fliser D, Frokiaer J, Garin J,
Girolami M, Hancock WS, Haubitz M, Hochstrasser D, Holman RR, Ioannidis JP,
Jankowski J, Julian BA, Klein JB, Kolch W, Luider T, Massy Z, Mattes WB, Molina
F, Monsarrat B, Novak J, Peter K, Rossing P, Sánchez-Carbayo M, Schanstra JP,
Semmes OJ, Spasovski G, Theodorescu D, Thongboonkerd V, Vanholder R, Veenstra TD,
Weissinger E, Yamamoto T, Vlahou A. Recommendations for biomarker identification
and qualification in clinical proteomics. Sci Transl Med. 2010 Aug
25;2(46):46ps42. doi: 10.1126/scitranslmed.3001249. PubMed PMID: 20739680.

127: Good DM, Zürbig P, Argilés A, Bauer HW, Behrens G, Coon JJ, Dakna M,
Decramer S, Delles C, Dominiczak AF, Ehrich JH, Eitner F, Fliser D, Frommberger
M, Ganser A, Girolami MA, Golovko I, Gwinner W, Haubitz M, Herget-Rosenthal S,
Jankowski J, Jahn H, Jerums G, Julian BA, Kellmann M, Kliem V, Kolch W, Krolewski
AS, Luppi M, Massy Z, Melter M, Neusüss C, Novak J, Peter K, Rossing K, Rupprecht
H, Schanstra JP, Schiffer E, Stolzenburg JU, Tarnow L, Theodorescu D,
Thongboonkerd V, Vanholder R, Weissinger EM, Mischak H, Schmitt-Kopplin P.
Naturally occurring human urinary peptides for use in diagnosis of chronic kidney
disease. Mol Cell Proteomics. 2010 Nov;9(11):2424-37. doi:
10.1074/mcp.M110.001917. Epub 2010 Jul 8. PubMed PMID: 20616184; PubMed Central
PMCID: PMC2984241.

128: Mischak H, Rossing P. Proteomic biomarkers in diabetic nephropathy--reality
or future promise? Nephrol Dial Transplant. 2010 Sep;25(9):2843-5. doi:
10.1093/ndt/gfq363. Epub 2010 Jun 22. PubMed PMID: 20571095.

129: Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H,
Kazanietz MG. A novel cross-talk in diacylglycerol signaling: the Rac-GAP
beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated
phosphorylation. J Biol Chem. 2010 May 28;285(22):16931-41. doi:
10.1074/jbc.M109.099036. Epub 2010 Mar 24. PubMed PMID: 20335173; PubMed Central
PMCID: PMC2878072.

130: Drube J, Zürbig P, Schiffer E, Lau E, Ure B, Glüer S, Kirschstein M, Pape L,
Decramer S, Bascands JL, Schanstra JP, Mischak H, Ehrich JH. Urinary proteome
analysis identifies infants but not older children requiring pyeloplasty. Pediatr
Nephrol. 2010 Sep;25(9):1673-8. doi: 10.1007/s00467-010-1455-8. Epub 2010 Feb 24.
PubMed PMID: 20180135.

131: Mischak H, Espandiari P, Sadrieh N, Hanig J. Profiling of rat urinary
proteomic patterns associated with drug-induced nephrotoxicity using CE coupled
with MS as a potential model for detection of drug-induced adverse effects.
Proteomics Clin Appl. 2009 Sep;3(9):1062-71. doi: 10.1002/prca.200900030. Epub
2009 Aug 26. PubMed PMID: 21137006.

132: Vlahou A, Allmaier G, Attwood T, Bongcam-Rudloff E, Charonis A, Frokiaer J,
Mischak H, Schanstra J, Spasovski G. 2nd Combined Working Group and Management
Committee Meeting of Urine and Kidney Proteomics COST Action 29-30 March 2009,
Nafplio, Greece. Proteomics Clin Appl. 2009 Sep;3(9):1017-22. doi:
10.1002/prca.200900087. Epub 2009 Aug 4. PubMed PMID: 21137004.

133: Mischak H, Massy ZA, Jankowski J. Proteomics in uremia and renal disease.
Semin Dial. 2009 Jul-Aug;22(4):409-16. doi: 10.1111/j.1525-139X.2009.00591.x.
Review. PubMed PMID: 19708992.

134: Vanholder R, Abou-Deif O, Argiles A, Baurmeister U, Beige J, Brouckaert P,
Brunet P, Cohen G, De Deyn PP, Drüeke TB, Fliser D, Glorieux G, Herget-Rosenthal
S, Hörl WH, Jankowski J, Jörres A, Massy ZA, Mischak H, Perna AF,
Rodriguez-Portillo JM, Spasovski G, Stegmayr BG, Stenvinkel P, Thornalley PJ,
Wanner C, Wiecek A. The role of EUTox in uremic toxin research. Semin Dial. 2009
Jul-Aug;22(4):323-8. doi: 10.1111/j.1525-139X.2009.00574.x. PubMed PMID:

135: Caubet C, Lacroix C, Decramer S, Drube J, Ehrich JH, Mischak H, Bascands JL,
Schanstra JP. Advances in urinary proteome analysis and biomarker discovery in
pediatric renal disease. Pediatr Nephrol. 2010 Jan;25(1):27-35. doi:
10.1007/s00467-009-1251-5. Epub 2009 Jul 15. Review. PubMed PMID: 19603189.

136: Schiffer E, Vlahou A, Petrolekas A, Stravodimos K, Tauber R, Geschwend JE,
Neuhaus J, Stolzenburg JU, Conaway MR, Mischak H, Theodorescu D. Prediction of
muscle-invasive bladder cancer using urinary proteomics. Clin Cancer Res. 2009
Aug 1;15(15):4935-43. doi: 10.1158/1078-0432.CCR-09-0226. Epub 2009 Jul 14.
PubMed PMID: 19602546.

137: Dhillon AS, Yip YY, Grindlay GJ, Pakay JL, Dangers M, Hillmann M, Clark W,
Pitt A, Mischak H, Kolch W. The C-terminus of Raf-1 acts as a 14-3-3-dependent
activation switch. Cell Signal. 2009 Nov;21(11):1645-51. doi:
10.1016/j.cellsig.2009.07.001. Epub 2009 Jul 10. PubMed PMID: 19595761.

138: Haubitz M, Good DM, Woywodt A, Haller H, Rupprecht H, Theodorescu D, Dakna
M, Coon JJ, Mischak H. Identification and validation of urinary biomarkers for
differential diagnosis and evaluation of therapeutic intervention in
anti-neutrophil cytoplasmic antibody-associated vasculitis. Mol Cell Proteomics.
2009 Oct;8(10):2296-307. doi: 10.1074/mcp.M800529-MCP200. Epub 2009 Jun 28.
PubMed PMID: 19564150; PubMed Central PMCID: PMC2758757.

139: Jankowski V, van der Giet M, Mischak H, Morgan M, Zidek W, Jankowski J.
Dinucleoside polyphosphates: strong endogenous agonists of the purinergic system.
Br J Pharmacol. 2009 Aug;157(7):1142-53. doi: 10.1111/j.1476-5381.2009.00337.x.
Epub 2009 Jun 25. Review. PubMed PMID: 19563527; PubMed Central PMCID:

140: Zürbig P, Schiffer E, Mischak H. Capillary electrophoresis coupled to mass
spectrometry for proteomic profiling of human urine and biomarker discovery.
Methods Mol Biol. 2009;564:105-21. doi: 10.1007/978-1-60761-157-8_6. PubMed PMID:

141: Weissinger EM, Mischak H, Kontsendorn J, Hahn A, Hahn N, Morgan M, Ganser A.
Proteome analysis in hematology using capillary electrophoresis coupled on-line
to mass spectrometry. Mini Rev Med Chem. 2009 May;9(5):627-3. Review. PubMed
PMID: 19456293.

142: Metzger J, Luppa PB, Good DM, Mischak H. Adapting mass spectrometry-based
platforms for clinical proteomics applications: The capillary electrophoresis
coupled mass spectrometry paradigm. Crit Rev Clin Lab Sci. 2009;46(3):129-52.
doi: 10.1080/10408360902805261. Review. PubMed PMID: 19404829.

143: Kistler AD, Mischak H, Poster D, Dakna M, Wüthrich RP, Serra AL.
Identification of a unique urinary biomarker profile in patients with autosomal
dominant polycystic kidney disease. Kidney Int. 2009 Jul;76(1):89-96. doi:
10.1038/ki.2009.93. Epub 2009 Apr 1. PubMed PMID: 19340089.

144: Zürbig P, Decramer S, Dakna M, Jantos J, Good DM, Coon JJ, Bandin F, Mischak
H, Bascands JL, Schanstra JP. The human urinary proteome reveals high similarity
between kidney aging and chronic kidney disease. Proteomics. 2009
Apr;9(8):2108-17. doi: 10.1002/pmic.200800560. PubMed PMID: 19296547; PubMed
Central PMCID: PMC2768386.

145: Drube J, Schiffer E, Mischak H, Kemper MJ, Neuhaus T, Pape L, Lichtinghagen
R, Ehrich JH. Urinary proteome pattern in children with renal Fanconi syndrome.
Nephrol Dial Transplant. 2009 Jul;24(7):2161-9. doi: 10.1093/ndt/gfp063. Epub
2009 Feb 18. PubMed PMID: 19225019.

146: Schiffer E, Mischak H, Zimmerli LU. Proteomics in gerontology: current
applications and future aspects--a mini-review. Gerontology. 2009;55(2):123-37.
doi: 10.1159/000191653. Epub 2009 Jan 9. Review. PubMed PMID: 19136815.

147: Snell-Bergeon JK, Maahs DM, Ogden LG, Kinney GL, Hokanson JE, Schiffer E,
Rewers M, Mischak H. Evaluation of urinary biomarkers for coronary artery
disease, diabetes, and diabetic kidney disease. Diabetes Technol Ther. 2009
Jan;11(1):1-9. doi: 10.1089/dia.2008.0040. PubMed PMID: 19132849; PubMed Central
PMCID: PMC2939844.

148: von Zur Muhlen C, Schiffer E, Zuerbig P, Kellmann M, Brasse M, Meert N,
Vanholder RC, Dominiczak AF, Chen YC, Mischak H, Bode C, Peter K. Evaluation of
urine proteome pattern analysis for its potential to reflect coronary artery
atherosclerosis in symptomatic patients. J Proteome Res. 2009 Jan;8(1):335-45.
doi: 10.1021/pr800615t. PubMed PMID: 19053529.

149: Jantos-Siwy J, Schiffer E, Brand K, Schumann G, Rossing K, Delles C, Mischak
H, Metzger J. Quantitative urinary proteome analysis for biomarker evaluation in
chronic kidney disease. J Proteome Res. 2009 Jan;8(1):268-81. doi:
10.1021/pr800401m. PubMed PMID: 19012428.

150: Dakna M, He Z, Yu WC, Mischak H, Kolch W. Technical, bioinformatical and
statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and
capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: a
critical assessment. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May
1;877(13):1250-8. doi: 10.1016/j.jchromb.2008.10.048. Epub 2008 Nov 6. Review.
PubMed PMID: 19010091.

151: Mischak H, Coon JJ, Novak J, Weissinger EM, Schanstra JP, Dominiczak AF.
Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker
discovery and clinical diagnosis: an update of recent developments. Mass Spectrom
Rev. 2009 Sep-Oct;28(5):703-24. doi: 10.1002/mas.20205. Review. PubMed PMID:
18973238; PubMed Central PMCID: PMC2720435.

152: Metzger J, Schanstra JP, Mischak H. Capillary electrophoresis-mass
spectrometry in urinary proteome analysis: current applications and future
developments. Anal Bioanal Chem. 2009 Mar;393(5):1431-42. doi:
10.1007/s00216-008-2309-0. Epub 2008 Aug 15. Review. PubMed PMID: 18704377.

153: Jiang H, Schiffer E, Song Z, Wang J, Zürbig P, Thedieck K, Moes S, Bantel H,
Saal N, Jantos J, Brecht M, Jenö P, Hall MN, Hager K, Manns MP, Hecker H, Ganser
A, Döhner K, Bartke A, Meissner C, Mischak H, Ju Z, Rudolph KL. Proteins induced
by telomere dysfunction and DNA damage represent biomarkers of human aging and
disease. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11299-304. doi:
10.1073/pnas.0801457105. Epub 2008 Aug 11. PubMed PMID: 18695223; PubMed Central
PMCID: PMC2516278.

154: Decramer S, Gonzalez de Peredo A, Breuil B, Mischak H, Monsarrat B, Bascands
JL, Schanstra JP. Urine in clinical proteomics. Mol Cell Proteomics. 2008
Oct;7(10):1850-62. doi: 10.1074/mcp.R800001-MCP200. Epub 2008 Jul 30. Review.
PubMed PMID: 18667409.

155: Vlahou A, Schanstra J, Frokiaer J, El Nahas M, Spasovski G, Mischak H, Domon
B, Allmaier G, Bongcam-Rudloff E, Attwood T; European Kidney and Urine Proteomics
Network. Establishment of a European Network for Urine and Kidney Proteomics. J
Proteomics. 2008 Oct 7;71(4):490-2. doi: 10.1016/j.jprot.2008.06.009. Epub 2008
Jun 22. PubMed PMID: 18620085.

156: Coon JJ, Zürbig P, Dakna M, Dominiczak AF, Decramer S, Fliser D, Frommberger
M, Golovko I, Good DM, Herget-Rosenthal S, Jankowski J, Julian BA, Kellmann M,
Kolch W, Massy Z, Novak J, Rossing K, Schanstra JP, Schiffer E, Theodorescu D,
Vanholder R, Weissinger EM, Mischak H, Schmitt-Kopplin P. CE-MS analysis of the
human urinary proteome for biomarker discovery and disease diagnostics.
Proteomics Clin Appl. 2008 Jul 10;2(7-8):964. PubMed PMID: 20130789; PubMed
Central PMCID: PMC2815342.

157: Rossing K, Mischak H, Rossing P, Schanstra JP, Wiseman A, Maahs DM. The
urinary proteome in diabetes and diabetes-associated complications: New ways to
assess disease progression and evaluate therapy. Proteomics Clin Appl. 2008
Jul;2(7-8):997-1007. doi: 10.1002/prca.200780166. Epub 2008 Jul 10. PubMed PMID:

158: Rossing K, Mischak H, Dakna M, Zürbig P, Novak J, Julian BA, Good DM, Coon
JJ, Tarnow L, Rossing P; PREDICTIONS Network. Urinary proteomics in diabetes and
CKD. J Am Soc Nephrol. 2008 Jul;19(7):1283-90. doi: 10.1681/ASN.2007091025. Epub
2008 Apr 30. PubMed PMID: 18448586; PubMed Central PMCID: PMC2440301.

159: Schiffer E, Mischak H, Vanholder RC. Exploring the uremic toxins using
proteomic technologies. Contrib Nephrol. 2008;160:159-71. doi: 10.1159/000125973.
Review. PubMed PMID: 18401168.

160: Decramer S, Zürbig P, Wittke S, Mischak H, Bascands JL, Schanstra JP.
Identification of urinary biomarkers by proteomics in newborns: use in
obstructive nephropathy. Contrib Nephrol. 2008;160:127-41. doi:
10.1159/000125956. Review. PubMed PMID: 18401166.

161: Zürbig P, Mischak H. Capillary electrophoresis coupled to mass spectrometry
for biomarker discovery and diagnosis of kidney diseases. Contrib Nephrol.
2008;160:107-26. doi: 10.1159/000125938. Review. PubMed PMID: 18401165.

162: Theodorescu D, Schiffer E, Bauer HW, Douwes F, Eichhorn F, Polley R, Schmidt
T, Schöfer W, Zürbig P, Good DM, Coon JJ, Mischak H. Discovery and validation of
urinary biomarkers for prostate cancer. Proteomics Clin Appl. 2008 Mar
7;2(4):556-570. PubMed PMID: 19759844; PubMed Central PMCID: PMC2744126.

163: Vanholder R, Baurmeister U, Brunet P, Cohen G, Glorieux G, Jankowski J;
European Uremic Toxin Work Group. A bench to bedside view of uremic toxins. J Am
Soc Nephrol. 2008 May;19(5):863-70. doi: 10.1681/ASN.2007121377. Epub 2008 Feb
20. Review. PubMed PMID: 18287557.

164: Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS,
Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari
SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE,
Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De
Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ,
Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C,
Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P,
Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K,
Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH,
Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I,
Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M,
Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens
L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA,
Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel
M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS,
Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier
GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH,
Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng
SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith
RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd
V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD,
Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR,
Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Human Proteinpedia enables sharing of
human protein data. Nat Biotechnol. 2008 Feb;26(2):164-7. doi:
10.1038/nbt0208-164. PubMed PMID: 18259167.

165: Schiffer E, Mischak H, Theodorescu D, Vlahou A. Challenges of using mass
spectrometry as a bladder cancer biomarker discovery platform. World J Urol. 2008
Feb;26(1):67-74. doi: 10.1007/s00345-007-0234-z. Epub 2008 Jan 4. Review. PubMed
PMID: 18175124.

166: Raedler TJ, Wittke S, Jahn H, Koessler A, Mischak H, Wiedemann K. Capillary
electrophoresis mass spectrometry as a potential tool to detect lithium-induced
nephropathy: Preliminary results. Prog Neuropsychopharmacol Biol Psychiatry. 2008
Apr 1;32(3):673-8. Epub 2007 Nov 23. PubMed PMID: 18155820.

167: Goodsaid F, Bandow JE, Mischak H. Grand rounds in proteomics at the FDA
white oak, silver spring, MD, USA, april 3, 2007. Proteomics Clin Appl. 2007
Dec;1(12):1526-31. doi: 10.1002/prca.200700575. PubMed PMID: 21136652.

168: Julian BA, Wittke S, Novak J, Good DM, Coon JJ, Kellmann M, Zürbig P,
Schiffer E, Haubitz M, Moldoveanu Z, Calcatera SM, Wyatt RJ, Sýkora J, Sládková
E, Hes O, Mischak H, McGuire BM. Electrophoretic methods for analysis of urinary
polypeptides in IgA-associated renal diseases. Electrophoresis. 2007
Dec;28(23):4469-83. PubMed PMID: 18004714.

169: Good DM, Thongboonkerd V, Novak J, Bascands JL, Schanstra JP, Coon JJ,
Dominiczak A, Mischak H. Body fluid proteomics for biomarker discovery: lessons
from the past hold the key to success in the future. J Proteome Res. 2007
Dec;6(12):4549-55. Epub 2007 Oct 31. Review. PubMed PMID: 17970587.

170: Zimmerli LU, Schiffer E, Zürbig P, Good DM, Kellmann M, Mouls L, Pitt AR,
Coon JJ, Schmieder RE, Peter KH, Mischak H, Kolch W, Delles C, Dominiczak AF.
Urinary proteomic biomarkers in coronary artery disease. Mol Cell Proteomics.
2008 Feb;7(2):290-8. Epub 2007 Oct 19. PubMed PMID: 17951555.

171: Theodorescu D, Mischak H. Mass spectrometry based proteomics in urine
biomarker discovery. World J Urol. 2007 Oct;25(5):435-43. Epub 2007 Aug 17.
Review. PubMed PMID: 17703310.

172: Weissinger EM, Mischak H. Application of proteomics to posttransplantational
follow-up. Methods Mol Med. 2007;134:217-28. PubMed PMID: 17666753.

173: Mischak H, Julian BA, Novak J. High-resolution proteome/peptidome analysis
of peptides and low-molecular-weight proteins in urine. Proteomics Clin Appl.
2007 Jul 10;1(8):792. PubMed PMID: 20107618; PubMed Central PMCID: PMC2811330.

174: Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I,
Schmitt-Kopplin P, Schiffer E. Peptidomic analysis of rat urine using capillary
electrophoresis coupled to mass spectrometry. Proteomics Clin Appl. 2007
Jul;1(7):650-60. doi: 10.1002/prca.200700195. Epub 2007 Jun 8. PubMed PMID:

175: Vanholder R, Meert N, Schepers E, Glorieux G, Argiles A, Brunet P, Cohen G,
Drüeke T, Mischak H, Spasovski G, Massy Z, Jankowski J; European Uremic Toxin
Work Group (EUTox). Review on uraemic solutes II--variability in reported
concentrations: causes and consequences. Nephrol Dial Transplant. 2007
Nov;22(11):3115-21. Epub 2007 Jun 5. Review. PubMed PMID: 17550927.

176: Sniehotta M, Schiffer E, Zürbig P, Novak J, Mischak H. CE - a
multifunctional application for clinical diagnosis. Electrophoresis. 2007
May;28(9):1407-17. Review. PubMed PMID: 17427258.

177: Fliser D, Novak J, Thongboonkerd V, Argilés A, Jankowski V, Girolami MA,
Jankowski J, Mischak H. Advances in urinary proteome analysis and biomarker
discovery. J Am Soc Nephrol. 2007 Apr;18(4):1057-71. Epub 2007 Feb 28. Review.
PubMed PMID: 17329573.

178: Mischak H, Apweiler R, Banks RE, Conaway M, Coon J, Dominiczak A, Ehrich JH,
Fliser D, Girolami M, Hermjakob H, Hochstrasser D, Jankowski J, Julian BA, Kolch
W, Massy ZA, Neusuess C, Novak J, Peter K, Rossing K, Schanstra J, Semmes OJ,
Theodorescu D, Thongboonkerd V, Weissinger EM, Van Eyk JE, Yamamoto T. Clinical
proteomics: A need to define the field and to begin to set adequate standards.
Proteomics Clin Appl. 2007 Feb;1(2):148-56. doi: 10.1002/prca.200600771. Epub
2007 Jan 22. PubMed PMID: 21136664.

179: Schiffer E, Mischak H, Novak J. High resolution proteome/peptidome analysis
of body fluids by capillary electrophoresis coupled with MS. Proteomics. 2006
Oct;6(20):5615-27. Review. PubMed PMID: 16991199.

180: Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I,
Pelzing M, Neusüss C, Theodorescu D, Root KE, Ross MM, Mischak H. Biomarker
discovery by CE-MS enables sequence analysis via MS/MS with platform-independent
separation. Electrophoresis. 2006 Jun;27(11):2111-25. PubMed PMID: 16645980.

181: Girolami M, Mischak H, Krebs R. Analysis of complex, multidimensional
datasets. Drug Discov Today Technol. 2006 Spring;3(1):13-9. doi:
10.1016/j.ddtec.2006.03.010. PubMed PMID: 24980097.

182: Decramer S, Wittke S, Mischak H, Zürbig P, Walden M, Bouissou F, Bascands
JL, Schanstra JP. Predicting the clinical outcome of congenital unilateral
ureteropelvic junction obstruction in newborn by urinary proteome analysis. Nat
Med. 2006 Apr;12(4):398-400. Epub 2006 Mar 19. PubMed PMID: 16550189.

183: Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H,
Frierson HF. Discovery and validation of new protein biomarkers for urothelial
cancer: a prospective analysis. Lancet Oncol. 2006 Mar;7(3):230-40. PubMed PMID:

184: Weissinger EM, Mischak H, Ganser A, Hertenstein B. Value of proteomics
applied to the follow-up in stem cell transplantation. Ann Hematol. 2006
Apr;85(4):205-11. Epub 2006 Feb 7. Review. PubMed PMID: 16463156.

185: Weissinger EM, Nguyen-Khoa T, Fumeron C, Saltiel C, Walden M, Kaiser T,
Mischak H, Drüeke TB, Lacour B, Massy ZA. Effects of oral vitamin C
supplementation in hemodialysis patients: a proteomic assessment. Proteomics.
2006 Feb;6(3):993-1000. PubMed PMID: 16372263.

186: Chalmers MJ, Mackay CL, Hendrickson CL, Wittke S, Walden M, Mischak H,
Fliser D, Just I, Marshall AG. Combined top-down and bottom-up mass spectrometric
approach to characterization of biomarkers for renal disease. Anal Chem. 2005 Nov
15;77(22):7163-71. PubMed PMID: 16285662.

187: Weissinger EM, Hertenstein B, Mischak H, Ganser A. Online coupling of
capillary electrophoresis with mass spectrometry for the identification of
biomarkers for clinical diagnosis. Expert Rev Proteomics. 2005 Oct;2(5):639-47.
Review. PubMed PMID: 16209644.

188: Wittke S, Haubitz M, Walden M, Rohde F, Schwarz A, Mengel M, Mischak H,
Haller H, Gwinner W. Detection of acute tubulointerstitial rejection by proteomic
analysis of urinary samples in renal transplant recipients. Am J Transplant. 2005
Oct;5(10):2479-88. PubMed PMID: 16162198.

189: Meier M, Kaiser T, Herrmann A, Knueppel S, Hillmann M, Koester P, Danne T,
Haller H, Fliser D, Mischak H. Identification of urinary protein pattern in type
1 diabetic adolescents with early diabetic nephropathy by a novel combined
proteome analysis. J Diabetes Complications. 2005 Jul-Aug;19(4):223-32. PubMed
PMID: 15993357.

190: Theodorescu D, Fliser D, Wittke S, Mischak H, Krebs R, Walden M, Ross M,
Eltze E, Bettendorf O, Wulfing C, Semjonow A. Pilot study of capillary
electrophoresis coupled to mass spectrometry as a tool to define potential
prostate cancer biomarkers in urine. Electrophoresis. 2005 Jul;26(14):2797-808.
PubMed PMID: 15981297.

191: Fliser D, Wittke S, Mischak H. Capillary electrophoresis coupled to mass
spectrometry for clinical diagnostic purposes. Electrophoresis. 2005
Jul;26(14):2708-16. Review. PubMed PMID: 15966014.

192: Rossing K, Mischak H, Parving HH, Christensen PK, Walden M, Hillmann M,
Kaiser T. Impact of diabetic nephropathy and angiotensin II receptor blockade on
urinary polypeptide patterns. Kidney Int. 2005 Jul;68(1):193-205. PubMed PMID:

193: Haubitz M, Wittke S, Weissinger EM, Walden M, Rupprecht HD, Floege J, Haller
H, Mischak H. Urine protein patterns can serve as diagnostic tools in patients
with IgA nephropathy. Kidney Int. 2005 Jun;67(6):2313-20. PubMed PMID: 15882273.

194: Kolch W, Mischak H, Pitt AR. The molecular make-up of a tumour: proteomics
in cancer research. Clin Sci (Lond). 2005 May;108(5):369-83. Review. PubMed PMID:

195: Wittke S, Mischak H, Walden M, Kolch W, Rädler T, Wiedemann K. Discovery of
biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis
coupled to mass spectrometry: towards new diagnostic and therapeutic approaches.
Electrophoresis. 2005 Apr;26(7-8):1476-87. PubMed PMID: 15765478.

196: Kolch W, Neusüss C, Pelzing M, Mischak H. Capillary electrophoresis-mass
spectrometry as a powerful tool in clinical diagnosis and biomarker discovery.
Mass Spectrom Rev. 2005 Nov-Dec;24(6):959-77. Review. PubMed PMID: 15747373.

197: Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley
JH. Structural mechanism for lipid activation of the Rac-specific GAP,
beta2-chimaerin. Cell. 2004 Oct 29;119(3):407-18. PubMed PMID: 15507211.

198: Weissinger EM, Kaiser T, Meert N, De Smet R, Walden M, Mischak H, Vanholder
RC. Proteomics: a novel tool to unravel the patho-physiology of uraemia. Nephrol
Dial Transplant. 2004 Dec;19(12):3068-77. Epub 2004 Oct 19. PubMed PMID:

199: Kolch W, Mischak H, Chalmers MJ, Pitt A, Marshall AG. Clinical proteomics: a
question of technology. Rapid Commun Mass Spectrom. 2004;18(19):2365-6. PubMed
PMID: 15384161.

200: Mischak H, Kaiser T, Walden M, Hillmann M, Wittke S, Herrmann A, Knueppel S,
Haller H, Fliser D. Proteomic analysis for the assessment of diabetic renal
damage in humans. Clin Sci (Lond). 2004 Nov;107(5):485-95. PubMed PMID: 15281910.

201: Schaefer M, Mischak H, Schnell S, Griese A, Iakubov R, Riepenhausen G,
Schöfl C. Mechanisms of arginine-vasopressin-induced Ca2+ oscillations in
beta-cells (HIT-T15): a role for oscillating protein kinase C. Endocrinology.
2004 Oct;145(10):4635-44. Epub 2004 Jul 8. PubMed PMID: 15242987.

202: Kaiser T, Wittke S, Just I, Krebs R, Bartel S, Fliser D, Mischak H,
Weissinger EM. Capillary electrophoresis coupled to mass spectrometer for
automated and robust polypeptide determination in body fluids for clinical use.
Electrophoresis. 2004 Jul;25(13):2044-55. PubMed PMID: 15237405.

203: Weissinger EM, Oettrich K, Evans C, Genieser HG, Schwede F, Dangers M,
Dammann E, Kolb HJ, Mischak H, Ganser A, Kolch W. Activation of protein kinase A
(PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy. Br J Cancer.
2004 Jul 5;91(1):186-92. PubMed PMID: 15188002; PubMed Central PMCID: PMC2364761.

204: Weissinger EM, Wittke S, Kaiser T, Haller H, Bartel S, Krebs R, Golovko I,
Rupprecht HD, Haubitz M, Hecker H, Mischak H, Fliser D. Proteomic patterns
established with capillary electrophoresis and mass spectrometry for diagnostic
purposes. Kidney Int. 2004 Jun;65(6):2426-34. PubMed PMID: 15149356.

205: Kaiser T, Kamal H, Rank A, Kolb HJ, Holler E, Ganser A, Hertenstein B,
Mischak H, Weissinger EM. Proteomics applied to the clinical follow-up of
patients after allogeneic hematopoietic stem cell transplantation. Blood. 2004
Jul 15;104(2):340-9. Epub 2004 Mar 30. PubMed PMID: 15054046.

206: Chalmers MJ, Kolch W, Emmett MR, Marshall AG, Mischak H. Identification and
analysis of phosphopeptides. J Chromatogr B Analyt Technol Biomed Life Sci. 2004
Apr 15;803(1):111-20. Review. PubMed PMID: 15026004.

207: Wittke S, Kaiser T, Mischak H. Differential polypeptide display: the search
for the elusive target. J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr
15;803(1):17-26. Review. PubMed PMID: 15025995.

208: Wang QJ, Lu G, Schlapkohl WA, Goerke A, Larsson C, Mischak H, Blumberg PM,
Mushinski JF. The V5 domain of protein kinase C plays a critical role in
determining the isoform-specific localization, translocation, and biological
function of protein kinase C-delta and -epsilon. Mol Cancer Res. 2004
Feb;2(2):129-40. PubMed PMID: 14985469.

209: Neuhoff Nv, Kaiser T, Wittke S, Krebs R, Pitt A, Burchard A, Sundmacher A,
Schlegelberger B, Kolch W, Mischak H. Mass spectrometry for the detection of
differentially expressed proteins: a comparison of surface-enhanced laser
desorption/ionization and capillary electrophoresis/mass spectrometry. Rapid
Commun Mass Spectrom. 2004;18(2):149-56. PubMed PMID: 14745763.

210: Wittke S, Fliser D, Haubitz M, Bartel S, Krebs R, Hausadel F, Hillmann M,
Golovko I, Koester P, Haller H, Kaiser T, Mischak H, Weissinger EM. Determination
of peptides and proteins in human urine with capillary electrophoresis-mass
spectrometry, a suitable tool for the establishment of new diagnostic markers. J
Chromatogr A. 2003 Sep 26;1013(1-2):173-81. PubMed PMID: 14604118.

211: Kaiser T, Hermann A, Kielstein JT, Wittke S, Bartel S, Krebs R, Hausadel F,
Hillmann M, Golovko I, Koester P, Haller H, Weissinger EM, Fliser D, Mischak H.
Capillary electrophoresis coupled to mass spectrometry to establish polypeptide
patterns in dialysis fluids. J Chromatogr A. 2003 Sep 26;1013(1-2):157-71. PubMed
PMID: 14604117.

212: Chalmers MJ, Quinn JP, Blakney GT, Emmett MR, Mischak H, Gaskell SJ,
Marshall AG. Liquid chromatography-Fourier transform ion cyclotron resonance mass
spectrometric characterization of protein kinase C phosphorylation. J Proteome
Res. 2003 Jul-Aug;2(4):373-82. PubMed PMID: 12938927.

213: Brandt DT, Goerke A, Heuer M, Gimona M, Leitges M, Kremmer E, Lammers R,
Haller H, Mischak H. Protein kinase C delta induces Src kinase activity via
activation of the protein tyrosine phosphatase PTP alpha. J Biol Chem. 2003 Sep
5;278(36):34073-8. Epub 2003 Jun 25. PubMed PMID: 12826681.

214: Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel
RG, Häring HU, Kellerer M. Protein kinase C delta activation and translocation to
the nucleus are required for fatty acid-induced apoptosis of insulin-secreting
cells. Diabetes. 2003 Apr;52(4):991-7. PubMed PMID: 12663471.

215: Dhillon AS, Meikle S, Peyssonnaux C, Grindlay J, Kaiser C, Steen H, Shaw PE,
Mischak H, Eychène A, Kolch W. A Raf-1 mutant that dissociates MEK/extracellular
signal-regulated kinase activation from malignant transformation and
differentiation but not proliferation. Mol Cell Biol. 2003 Mar;23(6):1983-93.
PubMed PMID: 12612072; PubMed Central PMCID: PMC149463.

216: Goerke A, Sakai N, Gutjahr E, Schlapkohl WA, Mushinski JF, Haller H, Kolch
W, Saito N, Mischak H. Induction of apoptosis by protein kinase C delta is
independent of its kinase activity. J Biol Chem. 2002 Aug 30;277(35):32054-62.
Epub 2002 Jun 7. PubMed PMID: 12055197.

217: Dhillon AS, Pollock C, Steen H, Shaw PE, Mischak H, Kolch W. Cyclic
AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine
259. Mol Cell Biol. 2002 May;22(10):3237-46. PubMed PMID: 11971957; PubMed
Central PMCID: PMC133783.

218: Brandt D, Gimona M, Hillmann M, Haller H, Mischak H. Protein kinase C
induces actin reorganization via a Src- and Rho-dependent pathway. J Biol Chem.
2002 Jun 7;277(23):20903-10. Epub 2002 Mar 29. PubMed PMID: 11925438.

219: Walter R, Mischak H, Haller H. Haemodialysis, atherosclerosis and
inflammation-identifying molecular mechanisms of chronic vascular disease in ESDR
patients. Nephrol Dial Transplant. 2002;17 Suppl 3:24-9. Review. PubMed PMID:

220: Hennige AM, Fritsche A, Strack V, Weigert C, Mischak H, Borboni P, Renn W,
Häring HU, Kellerer M. PKC zeta enhances insulin-like growth factor 1-dependent
mitogenic activity in the rat clonal beta cell line RIN 1046-38. Biochem Biophys
Res Commun. 2002 Jan 11;290(1):85-90. PubMed PMID: 11779137.

221: Krasel C, Dammeier S, Winstel R, Brockmann J, Mischak H, Lohse MJ.
Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by
calmodulin. J Biol Chem. 2001 Jan 19;276(3):1911-5. Epub 2000 Oct 19. PubMed
PMID: 11042191.

222: Janosch P, Kieser A, Eulitz M, Lovric J, Sauer G, Reichert M, Gounari F,
Büscher D, Baccarini M, Mischak H, Kolch W. The Raf-1 kinase associates with
vimentin kinases and regulates the structure of vimentin filaments. FASEB J. 2000
Oct;14(13):2008-21. PubMed PMID: 11023985.

223: Dammeier S, Lovric J, Eulitz M, Kolch W, Mushinski JF, Mischak H.
Identification of the smooth muscle-specific protein, sm22, as a novel protein
kinase C substrate using two-dimensional gel electrophoresis and mass
spectrometry. Electrophoresis. 2000 Jul;21(12):2443-53. PubMed PMID: 10939458.

224: Mai S, Hanley-Hyde J, Rainey GJ, Kuschak TI, Paul JT, Littlewood TD, Mischak
H, Stevens LM, Henderson DW, Mushinski JF. Chromosomal and extrachromosomal
instability of the cyclin D2 gene is induced by Myc overexpression. Neoplasia.
1999 Aug;1(3):241-52. PubMed PMID: 10935479; PubMed Central PMCID: PMC1508077.

225: Baumann M, Gires O, Kolch W, Mischak H, Zeidler R, Pich D, Hammerschmidt W.
The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator
protein BZLF1. Eur J Biochem. 2000 Jun;267(12):3891-901. PubMed PMID: 10849009.

226: Abraham D, Podar K, Pacher M, Kubicek M, Welzel N, Hemmings BA, Dilworth SM,
Mischak H, Kolch W, Baccarini M. Raf-1-associated protein phosphatase 2A as a
positive regulator of kinase activation. J Biol Chem. 2000 Jul
21;275(29):22300-4. PubMed PMID: 10801873.

227: Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W.
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase
pathway by the raf kinase inhibitor protein. Mol Cell Biol. 2000
May;20(9):3079-85. PubMed PMID: 10757792; PubMed Central PMCID: PMC85596.

228: Häcker H, Mischak H, Häcker G, Eser S, Prenzel N, Ullrich A, Wagner H. Cell
type-specific activation of mitogen-activated protein kinases by CpG-DNA controls
interleukin-12 release from antigen-presenting cells. EMBO J. 1999 Dec
15;18(24):6973-82. PubMed PMID: 10601019; PubMed Central PMCID: PMC1171760.

229: Cooper DR, Watson JE, Patel N, Illingworth P, Acevedo-Duncan M, Goodnight J,
Chalfant CE, Mischak H. Ectopic expression of protein kinase CbetaII, -delta, and
-epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose
uptake in NIH-3T3 cells. Arch Biochem Biophys. 1999 Dec 1;372(1):69-79. Erratum
in: Arch Biochem Biophys 2001 Apr 1;388(1):178. PubMed PMID: 10562418.

230: Caloca MJ, Garcia-Bermejo ML, Blumberg PM, Lewin NE, Kremmer E, Mischak H,
Wang S, Nacro K, Bienfait B, Marquez VE, Kazanietz MG. beta2-chimaerin is a novel
target for diacylglycerol: binding properties and changes in subcellular
localization mediated by ligand binding to its C1 domain. Proc Natl Acad Sci U S
A. 1999 Oct 12;96(21):11854-9. PubMed PMID: 10518540; PubMed Central PMCID:

231: Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis
KD, Rose DW, Mischak H, Sedivy JM, Kolch W. Suppression of Raf-1 kinase activity
and MAP kinase signalling by RKIP. Nature. 1999 Sep 9;401(6749):173-7. PubMed
PMID: 10490027.

232: Häcker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K,
Lipford GB, Wagner H. CpG-DNA-specific activation of antigen-presenting cells
requires stress kinase activity and is preceded by non-specific endocytosis and
endosomal maturation. EMBO J. 1998 Nov 2;17(21):6230-40. PubMed PMID: 9799232;
PubMed Central PMCID: PMC1170949.

233: Baumann M, Mischak H, Dammeier S, Kolch W, Gires O, Pich D, Zeidler R,
Delecluse HJ, Hammerschmidt W. Activation of the Epstein-Barr virus transcription
factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation. J
Virol. 1998 Oct;72(10):8105-14. PubMed PMID: 9733851; PubMed Central PMCID:

234: Lovrić J, Dammeier S, Kieser A, Mischak H, Kolch W. Activated raf induces
the hyperphosphorylation of stathmin and the reorganization of the microtubule
network. J Biol Chem. 1998 Aug 28;273(35):22848-55. PubMed PMID: 9712920.

235: Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Häring HU. Protein
kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to
inhibit the tyrosine kinase activity of the insulin receptor in human kidney
embryonic cells (HEK 293 cells). Diabetologia. 1998 Jul;41(7):833-8. PubMed PMID:

236: Wooten MW, Seibenhener ML, Heikkila JE, Mischak H. Delta-protein kinase C
phosphorylation parallels inhibition of nerve growth factor-induced
differentiation independent of changes in Trk A and MAP kinase signalling in PC12
cells. Cell Signal. 1998 Apr;10(4):265-76. PubMed PMID: 9617484.

237: Maucher C, Weissinger EM, Kremmer E, Baccarini M, Procyk K, Henderson DW,
Wolff L, Kolch W, Kaspers B, Mushinski JF, Mischak H. Activation of bcl-2
suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B
lymphocytic cell lines. FEBS Lett. 1998 May 1;427(1):29-35. PubMed PMID: 9613594.

238: Prouty SM, Maroo A, Maucher C, Mischak H, Kolch W, Sedivy JM. Studies of
perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts.
Biochim Biophys Acta. 1998 Mar 12;1402(1):6-16. PubMed PMID: 9551081.

239: Müller G, Storz P, Bourteele S, Döppler H, Pfizenmaier K, Mischak H, Philipp
A, Kaiser C, Kolch W. Regulation of Raf-1 kinase by TNF via its second messenger
ceramide and cross-talk with mitogenic signalling. EMBO J. 1998 Feb
2;17(3):732-42. PubMed PMID: 9450998; PubMed Central PMCID: PMC1170422.

240: Wang QJ, Acs P, Goodnight J, Blumberg PM, Mischak H, Mushinski JF. The
catalytic domain of PKC-epsilon, in reciprocal PKC-delta and -epsilon chimeras,
is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both
regulatory and catalytic domains of PKC-epsilon contribute to in vitro
transformation. Oncogene. 1998 Jan 8;16(1):53-60. PubMed PMID: 9467942.

241: Ueffing M, Lovrić J, Philipp A, Mischak H, Kolch W. Protein kinase C-epsilon
associates with the Raf-1 kinase and induces the production of growth factors
that stimulate Raf-1 activity. Oncogene. 1997 Dec 11;15(24):2921-7. PubMed PMID:

242: Kellerer M, Mushack J, Mischak H, Häring HU. Protein kinase C (PKC) epsilon
enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells.
FEBS Lett. 1997 Nov 24;418(1-2):119-22. PubMed PMID: 9414108.

243: Bossenmaier B, Mosthaf L, Mischak H, Ullrich A, Häring HU. Protein kinase C
isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin
receptor. Diabetologia. 1997 Jul;40(7):863-6. PubMed PMID: 9243110.

244: Weissinger EM, Eissner G, Grammer C, Fackler S, Haefner B, Yoon LS, Lu KS,
Bazarov A, Sedivy JM, Mischak H, Kolch W. Inhibition of the Raf-1 kinase by
cyclic AMP agonists causes apoptosis of v-abl-transformed cells. Mol Cell Biol.
1997 Jun;17(6):3229-41. PubMed PMID: 9154822; PubMed Central PMCID: PMC232176.

245: Wang QJ, Acs P, Goodnight J, Giese T, Blumberg PM, Mischak H, Mushinski JF.
The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon
chimeras mediates phorbol ester-induced macrophage differentiation of mouse
promyelocytes. J Biol Chem. 1997 Jan 3;272(1):76-82. PubMed PMID: 8995230.

246: Mischak H, Seitz T, Janosch P, Eulitz M, Steen H, Schellerer M, Philipp A,
Kolch W. Negative regulation of Raf-1 by phosphorylation of serine 621. Mol Cell
Biol. 1996 Oct;16(10):5409-18. PubMed PMID: 8816453; PubMed Central PMCID:

247: Kolch W, Philipp A, Mischak H, Dutil EM, Mullen TM, Feramisco JR, Meinkoth
JL, Rose DW. Inhibition of Raf-1 signaling by a monoclonal antibody, which
interferes with Raf-1 activation and with Mek substrate binding. Oncogene. 1996
Sep 19;13(6):1305-14. PubMed PMID: 8808705.

248: Kieser A, Seitz T, Adler HS, Coffer P, Kremmer E, Crespo P, Gutkind JS,
Henderson DW, Mushinski JF, Kolch W, Mischak H. Protein kinase C-zeta reverts
v-raf transformation of NIH-3T3 cells. Genes Dev. 1996 Jun 15;10(12):1455-66.
PubMed PMID: 8666230.

249: Janosch P, Schellerer M, Seitz T, Reim P, Eulitz M, Brielmeier M, Kölch W,
Sedivy JM, Mischak H. Characterization of IkappaB kinases. IkappaB-alpha is not
phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II
substrate. J Biol Chem. 1996 Jun 7;271(23):13868-74. PubMed PMID: 8662925.

250: Perletti GP, Folini M, Lin HC, Mischak H, Piccinini F, Tashjian AH Jr.
Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial
cells. Oncogene. 1996 Feb 15;12(4):847-54. PubMed PMID: 8632907.

251: Morawetz R, Lendenfeld T, Mischak H, Mühlbauer M, Gruber F, Goodnight J, de
Graaff LH, Visser J, Mushinski JF, Kubicek CP. Cloning and characterisation of
genes (pkc1 and pkcA) encoding protein kinase C homologues from Trichoderma
reesei and Aspergillus niger. Mol Gen Genet. 1996 Jan 15;250(1):17-28. PubMed
PMID: 8569684.

252: Kieser A, Goodnight J, Kölch W, Mischak H, Mushinski JF. Identification of
the primary growth response gene, ST2/T1, as a gene whose expression is
differentially regulated by different protein kinase C isozymes. FEBS Lett. 1995
Sep 25;372(2-3):189-93. PubMed PMID: 7556667.

253: Crespo P, Mischak H, Gutkind JS. Overexpression of mammalian protein kinase
C-zeta does not affect the growth characteristics of NIH 3T3 cells. Biochem
Biophys Res Commun. 1995 Aug 4;213(1):266-72. PubMed PMID: 7639744.

254: Chalfant CE, Mischak H, Watson JE, Winkler BC, Goodnight J, Farese RV,
Cooper DR. Regulation of alternative splicing of protein kinase C beta by
insulin. J Biol Chem. 1995 Jun 2;270(22):13326-32. PubMed PMID: 7768933.

255: Avignon A, Standaert ML, Yamada K, Mischak H, Spencer B, Farese RV. Insulin
increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and
protein kinase C-alpha, -beta and -theta in rat skeletal muscle. Biochem J. 1995
May 15;308 ( Pt 1):181-7. PubMed PMID: 7755564; PubMed Central PMCID: PMC1136861.

256: Goodnight JA, Mischak H, Kolch W, Mushinski JF. Immunocytochemical
localization of eight protein kinase C isozymes overexpressed in NIH 3T3
fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic
reticulum, and nuclear and cell membranes. J Biol Chem. 1995 Apr
28;270(17):9991-10001. PubMed PMID: 7730383.

257: Li S, Janosch P, Tanji M, Rosenfeld GC, Waymire JC, Mischak H, Kolch W,
Sedivy JM. Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.
EMBO J. 1995 Feb 15;14(4):685-96. PubMed PMID: 7882972; PubMed Central PMCID:

258: Goodnight J, Mischak H, Mushinski JF. Association of elevated levels of
protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia. Mol
Carcinog. 1994 Nov;11(3):131-7. PubMed PMID: 7945801.

259: Eissner G, Kölch W, Mischak H, Bornkamm GW, Holler E. Differential role of
protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro.
Scand J Immunol. 1994 Oct;40(4):395-402. PubMed PMID: 7939411.

260: Häfner S, Adler HS, Mischak H, Janosch P, Heidecker G, Wolfman A, Pippig S,
Lohse M, Ueffing M, Kolch W. Mechanism of inhibition of Raf-1 by protein kinase
A. Mol Cell Biol. 1994 Oct;14(10):6696-703. PubMed PMID: 7935389; PubMed Central
PMCID: PMC359200.

261: Morawetz R, Mischak H, Goodnight J, Lendenfeld T, Mushinsky JF, Kubicek CP.
A protein kinase-encoding gene, pkt1, from Trichoderma reesei, homologous to the
yeast YPK1 and YPK2 (YKR2) genes. Gene. 1994 Sep 2;146(2):309-10. PubMed PMID:

262: Yamada K, Standaert ML, Yu B, Mischak H, Cooper DR, Farese RV. Insulin-like
effects of sodium orthovanadate on diacylglycerol-protein kinase C signaling in
BC3H-1 myocytes. Arch Biochem Biophys. 1994 Jul;312(1):167-72. PubMed PMID:

263: Farese RV, Standaert ML, Arnold TP, Yamada K, Musunuru K, Hernandez H,
Mischak H, Cooper DR. Preferential activation of microsomal
diacylglycerol/protein kinase C signaling during glucose treatment (De Novo
phospholipid synthesis) of rat adipocytes. J Clin Invest. 1994 May;93(5):1894-9.
PubMed PMID: 8182122; PubMed Central PMCID: PMC294296.

264: Kazanietz MG, Bustelo XR, Barbacid M, Kolch W, Mischak H, Wong G, Pettit GR,
Bruns JD, Blumberg PM. Zinc finger domains and phorbol ester pharmacophore.
Analysis of binding to mutated form of protein kinase C zeta and the vav and
c-raf proto-oncogene products. J Biol Chem. 1994 Apr 15;269(15):11590-4. PubMed
PMID: 8157692.

265: Lehel C, Olah Z, Mischak H, Mushinski JF, Anderson WB. Overexpressed protein
kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential
subcellular localization and differential regulation of sodium-dependent
phosphate uptake. J Biol Chem. 1994 Feb 18;269(7):4761-6. PubMed PMID: 8106444.

266: Li W, Mischak H, Yu JC, Wang LM, Mushinski JF, Heidaran MA, Pierce JH.
Tyrosine phosphorylation of protein kinase C-delta in response to its activation.
J Biol Chem. 1994 Jan 28;269(4):2349-52. PubMed PMID: 7507923.

267: Weissinger EM, Henderson DW, Mischak H, Goodnight J, Mushinski JF. Induction
of plasmacytomas that secrete monoclonal anti-peptide antibodies by retroviral
transformation. J Immunol Methods. 1994 Jan 12;168(1):123-30. PubMed PMID:

268: Huppi K, Siwarski D, Goodnight J, Mischak H. Assignment of the protein
kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse
chromosome 14. Genomics. 1994 Jan 1;19(1):161-2. PubMed PMID: 8188219.

269: Goodnight J, Mischak H, Mushinski JF. Selective involvement of protein
kinase C isozymes in differentiation and neoplastic transformation. Adv Cancer
Res. 1994;64:159-209. Review. PubMed PMID: 7879658.

270: Arnold TP, Standaert ML, Hernandez H, Watson J, Mischak H, Kazanietz MG,
Zhao L, Cooper DR, Farese RV. Effects of insulin and phorbol esters on MARCKS
(myristoylated alanine-rich C-kinase substrate) phosphorylation (and other
parameters of protein kinase C activation) in rat adipocytes, rat soleus muscle
and BC3H-1 myocytes. Biochem J. 1993 Oct 1;295 ( Pt 1):155-64. PubMed PMID:
8216211; PubMed Central PMCID: PMC1134832.

271: Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF.
Phorbol ester-induced myeloid differentiation is mediated by protein kinase
C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and
-eta. J Biol Chem. 1993 Sep 25;268(27):20110-5. PubMed PMID: 8376369.

272: Kazanietz MG, Areces LB, Bahador A, Mischak H, Goodnight J, Mushinski JF,
Blumberg PM. Characterization of ligand and substrate specificity for the
calcium-dependent and calcium-independent protein kinase C isozymes. Mol
Pharmacol. 1993 Aug;44(2):298-307. PubMed PMID: 8355667.

273: Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller
G, Marmé D, Rapp UR. Protein kinase C alpha activates RAF-1 by direct
phosphorylation. Nature. 1993 Jul 15;364(6434):249-52. PubMed PMID: 8321321.

274: Mischak H, Goodnight J, Henderson DW, Osada S, Ohno S, Mushinski JF. Unique
expression pattern of protein kinase C-theta: high mRNA levels in normal mouse
testes and in T-lymphocytic cells and neoplasms. FEBS Lett. 1993 Jul
12;326(1-3):51-5. PubMed PMID: 8325388.

275: Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marmé
D, Schächtele C. Selective inhibition of protein kinase C isozymes by the
indolocarbazole Gö 6976. J Biol Chem. 1993 May 5;268(13):9194-7. PubMed PMID:

276: Weissinger EM, Mischak H, Goodnight J, Davidson WF, Mushinski JF. Addition
of constitutive c-myc expression to Abelson murine leukemia virus changes the
phenotype of the cells transformed by the virus from pre-B-cell lymphomas to
plasmacytomas. Mol Cell Biol. 1993 Apr;13(4):2578-85. PubMed PMID: 8455630;
PubMed Central PMCID: PMC359590.

277: Mischak H, Goodnight JA, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz
MG, Blumberg PM, Pierce JH, Mushinski JF. Overexpression of protein kinase
C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth,
morphology, anchorage dependence, and tumorigenicity. J Biol Chem. 1993 Mar
25;268(9):6090-6. PubMed PMID: 8454583.

278: Ozawa K, Szallasi Z, Kazanietz MG, Blumberg PM, Mischak H, Mushinski JF,
Beaven MA. Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C
mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells.
Reconstitution of secretory responses with Ca2+ and purified isozymes in washed
permeabilized cells. J Biol Chem. 1993 Jan 25;268(3):1749-56. PubMed PMID:

279: Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF, Mischak H. The cDNA
sequence, expression pattern and protein characteristics of mouse protein kinase
C-zeta. Gene. 1992 Dec 15;122(2):305-11. PubMed PMID: 1487145.

280: Dlugosz AA, Mischak H, Mushinski JF, Yuspa SH. Transcripts encoding protein
kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and
differentiating mouse keratinocytes in vitro and exhibit quantitative changes in
neoplastic cells. Mol Carcinog. 1992;5(4):286-92. PubMed PMID: 1379814.

281: Mischak H, Kolch W, Goodnight J, Davidson WF, Rapp U, Rose-John S, Mushinski
JF. Expression of protein kinase C genes in hemopoietic cells is cell-type- and B
cell-differentiation stage specific. J Immunol. 1991 Dec 1;147(11):3981-7. PubMed
PMID: 1940380.

282: Weissinger EM, Mischak H, Largaespada DA, Kaehler DA, Mitchell T, Smith-Gill
SJ, Risser R, Mushinski JF. Induction of plasmacytomas secreting antigen-specific
monoclonal antibodies with a retrovirus expressing v-abl and c-myc. Proc Natl
Acad Sci U S A. 1991 Oct 1;88(19):8735-9. PubMed PMID: 1924333; PubMed Central
PMCID: PMC52584.

283: Mischak H, Bodenteich A, Kolch W, Goodnight J, Hofer F, Mushinski JF. Mouse
protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells:
sequence of the cDNA, expression patterns, and characterization of the protein.
Biochemistry. 1991 Aug 13;30(32):7925-31. PubMed PMID: 1868068.

284: Mischak H, Kolch W, Hofer F, Weissinger E, Gessl A, Davidson WF, Aiello FB,
Blaas D, Rapp UR. A raf/myc virus immortalized macrophage cell line which
supports the growth of B-cell and B-cell hybridomas. Oncogene. 1990
Sep;5(9):1377-82. PubMed PMID: 2216460.

285: Kolch W, Weissinger E, Mischak H, Troppmair J, Showalter SD, Lloyd P,
Heidecker G, Rapp UR. Probing structure and function of the raf protein kinase
domain with monoclonal antibodies. Oncogene. 1990 May;5(5):713-20. PubMed PMID:

286: Largaespada D, Kaehler D, Weissinger E, Mischak H, Mushinski F, Risser R.
The activity of an ABL-MYC retrovirus in fibroblast cell lines and in
lymphocytes. Curr Top Microbiol Immunol. 1990;166:91-6. PubMed PMID: 2073821.

287: Weissinger EM, Largaespada D, Smith-Gill SJ, Risser R, Mushinski JF, Mischak
H. A retrovirus expressing v-abl and c-myc induces plasmacytomas in 100% of adult
pristane-primed BALB/c mice. Curr Top Microbiol Immunol. 1990;166:121-7. PubMed
PMID: 2073789.

288: Mischak H, Hofer F, Messner R, Weissinger E, Hayn M, Tomme P, Esterbauer H,
Küchler E, Claeyssens M, Kubicek CP. Monoclonal antibodies against different
domains of cellobiohydrolase I and II from Trichoderma reesei. Biochim Biophys
Acta. 1989 Jan 27;990(1):1-7. PubMed PMID: 2914146.

289: Mischak H, Neubauer C, Berger B, Kuechler E, Blaas D. Detection of the human
rhinovirus minor group receptor on renaturing Western blots. J Gen Virol. 1988
Oct;69 ( Pt 10):2653-6. PubMed PMID: 2844972.

290: Mischak H, Neubauer C, Kuechler E, Blaas D. Characteristics of the minor
group receptor of human rhinoviruses. Virology. 1988 Mar;163(1):19-25. PubMed
PMID: 2831654.

291: Kowalski H, Maurer-Fogy I, Zorn M, Mischak H, Kuechler E, Blaas D. Cleavage
site between VP1 and P2A of human rhinovirus is different in serotypes 2 and 14.
J Gen Virol. 1987 Dec;68 ( Pt 12):3197-200. PubMed PMID: 2826658.