News | 2008
October 30, 2008
Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: An update of recent developments
Proteome analysis has emerged as a powerful technology to decipher biological processes. One of the main goals is to discover biomarkers for diseases from tissues and body fluids. However, the complexity and wide dynamic range of protein expression present an enormous challenge to separation technologies and mass spectrometry (MS) ...
October 7, 2008
Establishment of a European Network for Urine and Kidney Proteomics
Chronic kidney diseases (CKD) constitute a major and global healthcare threat, which is expected to be amplified in the near future owing to the rising numbers of aged individuals and the increased incidence of type II diabetes. It is also likely to have an impact on the overall mortality from chronic, non-communicable, disease worldwide ...
September 24, 2008
Fragments of Collagen allow discrimination of superficial and invasive bladder cancer tumors
Mosaiques diagnostics and an international network of renowned scientists revealed urinary fragments of collagen alpha-1(I) and alpha-1(III) to distinguish between superficial and invasive bladder cancer tumors.
August 15, 2008
Biomarkers unmask Biological Age
Newly identified peptides represent powerful biomarkers of human aging associated with telomere shortening and could be used in the clinic to improve personalized therapies in the elderly. Furthermore, the new test enables the assessment of food supplements, pharmacological therapies, and rules of behavior to retard premature aging.
View Press Release (German)
August 12, 2008
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
Telomere dysfunction limits the proliferative capacity of human cells by activation of DNA damage responses, inducing senescence or apoptosis. In humans, telomere shortening occurs in the vast majority of tissues during aging, and telomere shortening is accelerated in chronic diseases that increase the rate of cell turnover ...
July 10, 2008
CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics
Owing to its availability, ease of collection, and correlation with pathophysiology of diseases, urine is an attractive source for clinical proteomics. However, many proteomic studies have had only limited clinical impact, due to factors such as modest numbers of subjects, absence of disease controls, small numbers of defined biomarkers, and diversity of analytical platforms ...
July 10, 2008
The urinary proteome in diabetes and diabetes-associated complications: New ways to assess disease progression and evaluate therapy
Diabetes represents one of the main chronic diseases worldwide. Diabetes and its associated complications may be detectable even at early stages in the urinary proteome. In this article we review the current literature on urinary proteomics applied to the study of diabetes and diabetic complications ...
July 1, 2008
Urinary proteomics in diabetes and CKD
Urinary biomarkers for diabetes, diabetic nephropathy, and nondiabetic proteinuric renal diseases were sought. For 305 individuals, biomarkers were defined and validated in blinded data sets using high-resolution capillary electrophoresis coupled with electrospray-ionization mass spectrometry ...
May 31, 2008
Exploring the uremic toxins using proteomic technologies
Kidney failure leads to the uremic syndrome that is the clinical expression of the malfunction of vital organs due to the accumulation of uremic toxins, which are normally cleared by the kidneys. Progressively more uremic retention solutes have been identified and their potential toxicity has been characterized ...
May 31, 2008
Identification of urinary biomarkers by proteomics in newborns: use in obstructive nephropathy
An important issue in congenital unilateral ureteropelvic junction (UPJ) obstruction, a frequent pathology in newborns, is whether infants should undergo surgery. Non-invasive biomarkers to reduce or replace the current invasive clinical exploration are not available ...
May 31, 2008
Capillary electrophoresis coupled to mass spectrometry for biomarker discovery and diagnosis of kidney diseases
The main focus of urinary proteome analysis in nephrology is currently on detection and identification of polypeptides that significantly alter (in abundance, distribution, etc.) during (patho)physiological changes of the kidney structure and/or function. Capillary electrophoresis coupled online to electrospray ionization time-of-flight mass spectrometry (CE-MS) was applied to human urine to identify biomarkers for clinical diagnostics ...
May 1, 2008
A bench to bedside view of uremic toxins
Reviewing the current picture of uremic toxicity reveals its complexity. Focusing on cardiovascular damage as a model of uremic effects resulting in substantial morbidity and mortality, most molecules with potential to affect the function of a variety of cell types within the vascular system are difficult to remove by dialysis ...
April 1, 2008
Capillary electrophoresis mass spectrometry as a potential tool to detect lithium-induced nephropathy: Preliminary results
Lithium remains the treatment of choice for many patients suffering from bipolar disorder. However, long-term treatment with lithium carries the potential to cause renal and thyroid dysfunction …
March 7, 2008
Innovative urine analysis improves prostate cancer diagnosis
Mosaiques´ CE/MS technology demonstrates its groundbreaking capabilities in a blinded prospective multicenter study with more than 500 patients in order to improve prostate cancer diagnosis.
February 28, 2008
Advances in urinary proteome analysis and biomarker discovery
Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still challenges in clinical nephrology. Definition of biomarkers on the basis of proteome analysis, especially of the urine, has advanced recently and may provide new tools to solve those challenges ...
February 1, 2008
Human Proteinpedia enables sharing of human protein data
Proteomic technologies, such as yeast twohybrid, mass spectrometry (MS), protein/peptide arrays and fluorescence microscopy, yield multi-dimensional data sets, which are often quite large and either not published or published as supplementary information that is not easily searchable. Without a system in place for standardizing and sharing data, it is not fruitful for the biomedical community to contribute these types of data to centralized repositories ...
January 4, 2008
Challenges of using mass spectrometry as a bladder cancer biomarker discovery platform
Bladder cancer (BCa) is one of the most prevalent malignancies worldwide, mostly due to its high recurrence rates. In consequence, the necessity of repeated screening for reappearance demonstrates the urgent need for novel biomarkers as alternatives to invasive standard procedures ...