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Bibliography
Dakna M, He Z, Yu WC, Mischak H, Kolch W
Technical, bioinformatical and statistical aspects of LC-MS and CE-MS based clinical Proteomics: a critical assessment
Journal of Chromatography B 2009, in press
Mischak H, Jankowski J
Proteomics and uremia and renal disease
Seminars in Dialysis 2009, in press
Zürbig P, Decramer S, Dakna M, Jantos J, Good DM, Coon JJ, Mischak H, Bascands JL, Schanstra JP
A low molecular weight urinary proteome profile of human aging
PROTEOMICS 2009, in press
Schiffer E, Mischak H, Zimmerli LU
Proteomics in gerontology - current applications and future aspects
Gerontology 2009, in press
Muhlen C, Schiffer E, Zuerbig P, Kellmann M, Brasse M, Meert N, Vanholder RC, Dominiczak AF, Chen YC, Mischak H, Bode C, Peter K
Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients
Journal of Proteome Research 2009, 8(1): 335-345
Snell-Bergeon JK, Maahs DM, Ogden LG, Kinney GL, Hokanson JE, Schiffer E, Mischak H, Rewers M
Evaluation of urinary biomarkers for coronary artery disease, diabetes, and diabetic kidney disease
Diabetes, Technology and Therapeutics 2009, 11(1): 1-9
Mischak H, Coon JJ, Novak J, Weissinger EM, Schanstra J, Dominiczak AF
Capillary electrophoresis-mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments
Mass Spectrometry Reviews 2009, in press
Jantos-Siwy J, Schiffer E, Brand K, Schumann G, Rossing K, Delles C, Mischak H, Metzger J
Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease
Journal of Proteome Research 2009, 8(1): 268-281
Metzger J, Schanstra JP, Mischak H
Capillary electrophoresis-mass spectrometry in urinary proteome analysis: current applications and future developments
Analytical and Bioanalytical Chemistry 2009, in press
Haubitz M, Mischak H, Julian BA, Novak J
Urinary Protein Patterns as a Diagnostic Tool for Patients with Immunoglobulin A Nephropathy
European Renal Disease - Touch Briefings 2009, in press
Vlahou A, Schanstra J, Frokiaer J, El Nahas M, Spasovski G, Mischak H, Domon B, Allmaier G, Bongcam-Rudloff E, Attwood T; On behalf of the European Kidney and Urine Proteomics Network
Establishment of a European Network for Urine and Kidney Proteomics
J Proteomics 2008, 71(4): 490-492
Decramer S, Gonzalez de Peredo A, Breuil B, Mischak H, Monsarrat B, Bascands JL, Schanstra JP
Urine in clinical proteomics
Mol Cell Proteomics 2008, 7(10): 1850-1862
Jiang H, Schiffer E, Song Z, Wang J, Zurbig P, Thedieck K, Moes S, Bantel H, Saal N, Jantos J, Brecht M, Jenoe P, Hall MN, Hager K, Manns MP, Hecker H, Ganser A, Doehner K, Bartke A, Meissner C, Mischak H, Ju Z, Rudolph KL
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease
Proc Natl Acad Sci (USA) 2008, 105(32): 11299-11304
Vanholder R, Baurmeister U, Brunet P, Cohen G, Glorieux G, Jankowski J
A bench to bedside view of uremic toxins
J Am Soc Nephrol. 2008, 19: 863-870
Coon JJ, Zurbig P, Dakna M, Dominiczak AF, Decramer S, Fliser D, Frommberger M, Golovko I, Good DM, Herget-Rosenthal S, Jankowski J, Julian BA, Kellmann M, Kolch W, Massy Z, Novak J, Rossing K, Schanstra JP, Schiffer E, Theodorescu D, Vanholder R, Weissinger EM, Mischak H, Schmitt-Kopplin P
CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics
PROTEOMICS - Clinical Applications 2008, 2(7-8): 964-973
Schiffer E, Mischak H, Vanholder RC
Exploring the uremic toxins using proteomic technologies
Contrib Nephrol. 2008, 160: 159-171
Decramer S, Zurbig P, Wittke S, Mischak H, Bascands JL, Schanstra JP
Identification of urinary biomarkers by proteomics in newborns: use in obstructive nephropathy
Contrib Nephrol. 2008, 160: 127-141
Zurbig P, Mischak H
Capillary electrophoresis coupled to mass spectrometry for biomarker discovery and diagnosis of kidney diseases
Contrib Nephrol. 2008, 160: 107-126
Rossing K, Mischak H, Rossing P, Schanstra JP, Wiseman A, Maahs DM
The urinary proteome in diabetes and diabetes-associated complications: new ways to assess disease progression and evaluate therapy
PROTEOMICS - Clinical Applications 2008, 2(7-8): 997-1007
Raedler T, Wittke S, Jahn H, Kössler A, Mischak H, Wiedemann K
Capillary electrophoresis mass spectrometry as a potential tool to detect lithium-induced nephropathy: Preliminary results
Prog Neuropsychopharmacol Biol Psychiatry 2008, 32(3): 673-678
Rossing K, Mischak H, Dakna M, Zürbig P, Novak J, Julian BA, Good DM, Coon JJ, Tarnow L, Rossing P
Proteomic Discovery and Evaluation of Urinary Biomarkers for Diabetes and Chronic Renal Disease
J Am Soc Nephrol. 2008, 19(7): 1283-1290
Schiffer E, Mischak H, Theodorescu, Vlahou A
Challenges of using mass spectrometry as a bladder cancer biomarker discovery platform
World Journal of Urology 2008, 26(1): 67-74
Theodorescu D, Schiffer E, Bauer HW, Douwes F, Eichhorn F, Polley R, Schmidt T, Schöfer W, Zurbig P, Good DM, Coon JJ, Mischak H
Discovery and validation of urinary biomarkers for prostate cancer
PROTEOMICS - Clinical Applications 2008, 2(4): 556-570
Mathivanan S, et al., Mischak H, et al., Zurbig P, Pandey A
Human Proteinpedia: A portal for sharing and integration of human protein data
Nature Biotechnology 2008, 26(2): 164-167
Zimmerli LU, Schiffer E, Zurbig P, Good DM, Kellmann M, Mouls L, Pitt AR, Coon JJ, Schmieder RE, Peter K, Mischak H, Kolch W, Delles C, Dominiczak AF
Urinary proteomic biomarkers in coronary artery disease
Mol Cell Proteomics 2008, 7(2): 290-298
Goodsaid F, Bandow JE, Mischak H
REPORT - Grand Rounds in Proteomics at the FDA (White Oak, Silver Spring, MD, USA, April 3, 2007)
PROTEOMICS - Clinical Applications 2007, 1: 1526-1531
Good DM, Thongboonkerd V, Novak J, Bascands JL, Schanstra JP, Coon JJ, Dominiczak A, Mischak H
Body Fluid Proteomics for Biomarker Discovery: Lessons from the Past Hold the Key to Success in the Future
J Proteome Res. 2007, 6(12): 4549-4555
Julian BA, Wittke S, Novak J, Good D, Coon JJ, Kellmann M, Zuerbig P, Schiffer E, Haubitz M, Moldoveanu Z, Calcatera S, Wyatt R, Sykora J, Sladkova E, Hes O, Mischak H, Mc Guire B
Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases
Electrophoresis 2007, 28(23): 4469-4483
Vanholder R, Meert N, Schepers E, Glorieux G, Argiles A, Brunet P, Cohen G, Drueke T, Mischak H, Spasovski G, Massy Z, Jankowski J; for the European Uremic Toxin Work Group (EUTox)
Review on uraemic solutes II Variability in reported concentrations: causes and consequences
Nephrol Dial Transplant. 2007, 22(11): 3115-3121
Julian BA, Wittke S, Haubitz M, Zürbig P, Schiffer E, McGuire BM, Wyatt RJ, Novak J
Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases
World Journal of Urology 2007, 35(5): 467-476
Decramer S, Bascands JL, Schanstra JP
Non-invasive markers of ureteropelvic junction obstruction
World Journal of Urology 2007, 25(5): 457-465
Weissinger EM, Schiffer E, Hertenstein B, Ferrara JL, Holler E, Stadler M, Kolb HJ, Zander A, Zürbig P, Kellmann M, Ganser A
Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Blood 2007, 109(12): 5511-5519
Ehrich J, Mischak A, Mischak H
Proteomanalyse
Österreichische Ärztezeitung 2007, 6: 49-53
Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I, Schmitt-Kopplin P, Schiffer E
Peptidomic analysis of rat urine using capillary electrophoresis coupled to mass spectrometry
PROTEOMICS - Clinical Applications 2007, 1: 650-660
Mischak H, Julian BA, Novak A
High-resolution proteome/peptidome analysis of peptides and low-molecular-weight proteins in urine
PROTEOMICS - Clinical Applications 2007, 1: 792-804
Mischak H, Apweiler R, Banks RE, Conaway M, Coon J, Dominiczak A, Ehrich JHH, Fliser D, Girolami M, Hermjakob H, Hochstrasser D, Jankowski J, Julian BA, Kolch W, Massy ZA, Neusuess C, Novak J, Peter K, Rossing K, Schanstra J, Semmes OJ, Theodorescu D, Thongboonkerd V, Weissinger EM, van Eyk JE, Yamamoto T
Clinical Proteomics: a need to define the field and to begin to set adequate standards
PROTEOMICS - Clinical Applications 2007, 1: 148-156
Theodorescu D, Mischak H
Mass spectrometry based proteomics in urine biomarker discovery
World J Urol. 2007, 25(5): 435-443
Weissinger EM, Mischak H
Application of proteomics to posttransplantational follow-up
Methods Mol Med. 2007, 134: 217-228
Sniehotta M, Schiffer E, Zurbig P, Novak J, Mischak H
CE - a multifunctional application for clinical diagnosis
Electrophoresis 2007, 28(9): 1407-1417
Fliser D, Novak J, Thongboonkerd V, Argiles A, Jankowski V, Girolami MA, Jankowski J, Mischak H
Advances in urinary proteome analysis and biomarker discovery
J Am Soc Nephrol. 2007, 18(4): 1057-1071
Schiffer E, Mischak H, Novak J
High resolution proteome/peptidome analysis of body fluids by capillary electrophoresis coupled with MS
Proteomics 2006, 6(20): 5615-5627
Zurbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzing M, Neususs C, Theodorescu D, Root KE, Ross MM, Mischak H
Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separation
Electrophoresis. 2006, 27(11): 2111-2125
Decramer S, Wittke S, Mischak H, Zurbig P, Walden M, Bouissou F, Bascands JL, Schanstra JP
Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis
Nat Med. 2006, 12(4): 398-400
Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis
Lancet Oncol. 2006, 7(3): 230-240
Weissinger EM, Mischak H, Ganser A, Hertenstein B
Value of proteomics applied to the follow-up in stem cell transplantation
Ann Hematol. 2006, 85(4): 205-211
Weissinger EM, Nguyen-Khoa T, Fumeron C, Saltiel C, Walden M, Kaiser T, Mischak H, Drueke TB, Lacour B, Massy ZA
Effects of oral vitamin C supplementation in hemodialysis patients: a proteomic assessment
Proteomics. 2006, 6(3): 993-1000
Chalmers MJ, Mackay CL, Hendrickson CL, Wittke S, Walden M, Mischak H, Fliser D, Just I, Marshall AG
Combined top-down and bottom-up mass spectrometric approach to characterization of biomarkers for renal disease
Anal Chem. 2005, 77(22): 7163-7171
Weissinger EM, Hertenstein B, Mischak H, Ganser A
Online coupling of capillary electrophoresis with mass spectrometry for the identification of biomarkers for clinical diagnosis
Expert Rev Proteomics 2005, 2(5): 639-647
Wittke S, Haubitz M, Walden M, Rohde F, Schwarz A, Mengel M, Mischak H, Haller H, Gwinner W
Detection of acute tubulointerstitial rejection by proteomic analysis of urinary samples in renal transplant recipients
Am J Transplant. 2005, 5(10): 2479-2488
Meier M, Kaiser T, Herrmann A, Knueppel S, Hillmann M, Koester P, Danne T, Haller H, Fliser D, Mischak H
Identification of urinary protein pattern in type 1 diabetic adolescents with early diabetic nephropathy by a novel combined proteome analysis
J Diabetes Complications 2005, 19(4): 223-232
Theodorescu D, Fliser D, Wittke S, Mischak H, Krebs R, Walden M, Ross M, Eltze E, Bettendorf O, Wulfing C, Semjonow A
Pilot study of capillary electrophoresis coupled to mass spectrometry as a tool to define potential prostate cancer biomarkers in urine
Electrophoresis 2005, 26(14): 2797-2808
Fliser D, Wittke S, Mischak H
Capillary electrophoresis coupled to mass spectrometry for clinical diagnostic purposes
Electrophoresis 2005, 26(14): 2708-2716
Rossing K, Mischak H, Parving HH, Christensen PK, Walden M, Hillmann M, Kaiser T
Impact of diabetic nephropathy and angiotensin II receptor blockade on urinary polypeptide patterns
Kidney Int. 2005, 68(1): 193-205
Haubitz M, Wittke S, Weissinger EM, Walden M, Rupprecht HD, Floege J, Haller H, Mischak H
Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy
Kidney Int. 2005, 67(6): 2313-2320
Kolch W, Mischak H, Pitt AR
The molecular make-up of a tumour: proteomics in cancer research
Clin Sci (Lond). 2005, 108(5): 369-383
Wittke S, Mischak H, Walden M, Kolch W, Radler T, Wiedemann K
Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches
Electrophoresis. 2005, 26(7-8): 1476-1487
Kolch W, Neususs C, Pelzing M, Mischak H
Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery
Mass Spectrom Rev. 2005, 24(6): 959-977
Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin
Cell 2004, 119(3): 407-418
Weissinger EM, Kaiser T, Meert N, De Smet R, Walden M, Mischak H, Vanholder RC
Proteomics: a novel tool to unravel the patho-physiology of uraemia
Nephrol Dial Transplant. 2004, 19(12): 3068-3077
Kolch W, Mischak H, Chalmers MJ, Pitt A, Marshall AG
Clinical proteomics: a question of technology
Rapid Commun Mass Spectrom. 2004, 18(19): 2365-2366
Mischak H, Kaiser T, Walden M, Hillmann M, Wittke S, Herrmann A, Knueppel S, Haller H, Fliser D
Proteomic analysis for the assessment of diabetic renal damage in humans
Clin Sci (Lond). 2004, 107(5): 485-495
Schaefer M, Mischak H, Schnell S, Griese A, Iakubov R, Riepenhausen G, Schofl C
Mechanisms of arginine-vasopressin-induced Ca2+ oscillations in beta-cells (HIT-T15): a role for oscillating protein kinase C
Endocrinology 2004, 145(10): 4635-4644
Kaiser T, Wittke S, Just I, Krebs R, Bartel S, Fliser D, Mischak H, Weissinger EM
Capillary electrophoresis coupled to mass spectrometer for automated and robust polypeptide determination in body fluids for clinical use
Electrophoresis 2004, 25(13): 2044-2055
Weissinger EM, Oettrich K, Evans C, Genieser HG, Schwede F, Dangers M, Dammann E, Kolb HJ, Mischak H, Ganser A, Kolch W
Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy
Br J Cancer. 2004, 91(1): 186-192
Weissinger EM, Wittke S, Kaiser T, Haller H, Bartel S, Krebs R, Golovko I, Rupprecht HD, Haubitz M, Hecker H, Mischak H, Fliser D
Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes
Kidney Int. 2004, 65(6): 2426-2434
Kaiser T, Kamal H, Rank A, Kolb HJ, Holler E, Ganser A, Hertenstein B, Mischak H, Weissinger EM
Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation
Blood 2004, 104(2): 340-349
Chalmers MJ, Kolch W, Emmett MR, Marshall AG, Mischak H
Identification and analysis of phosphopeptides
J Chromatogr B Analyt Technol Biomed Life Sci. 2004, 803(1): 111-120
Wittke S, Kaiser T, Mischak H
Differential polypeptide display: the search for the elusive target
J Chromatogr B Analyt Technol Biomed Life Sci. 2004, 803(1): 17-26
Wang QJ, Lu G, Schlapkohl WA, Goerke A, Larsson C, Mischak H, Blumberg PM, Mushinski JF
The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-delta and -epsilon
Mol Cancer Res. 2004, 2(2): 129-140
Neuhoff N, Kaiser T, Wittke S, Krebs R, Pitt A, Burchard A, Sundmacher A, Schlegelberger B, Kolch W, Mischak H
Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry
Rapid Commun Mass Spectrom. 2004, 18(2): 149-156
Wittke S, Fliser D, Haubitz M, Bartel S, Krebs R, Hausadel F, Hillmann M, Golovko I, Koester P, Haller H, Kaiser T, Mischak H, Weissinger EM
Determination of peptides and proteins in human urine with capillary electrophoresis-mass spectrometry, a suitable tool for the establishment of new diagnostic markers
J Chromatogr A. 2003, 1013(1-2): 173-181
Kaiser T, Hermann A, Kielstein JT, Wittke S, Bartel S, Krebs R, Hausadel F, Hillmann M, Golovko I, Koester P, Haller H, Weissinger EM, Fliser D, Mischak H
Capillary electrophoresis coupled to mass spectrometry to establish polypeptide patterns in dialysis fluids
J Chromatogr A. 2003, 1013(1-2): 157-171
Chalmers MJ, Quinn JP, Blakney GT, Emmett MR, Mischak H, Gaskell SJ, Marshall AG
Liquid chromatography-Fourier transform ion cyclotron resonance mass spectrometric characterization of protein kinase C phosphorylation
J Proteome Res. 2003, 2(4): 373-382
Brandt DT, Goerke A, Heuer M, Gimona M, Leitges M, Kremmer E, Lammers R, Haller H, Mischak H
Protein kinase C delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha
J Biol Chem. 2003, 278(36): 34073-34078
Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Haring HU, Kellerer M
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells
Diabetes 2003, 52(4): 991-997
Dhillon AS, Meikle S, Peyssonnaux C, Grindlay J, Kaiser C, Steen H, Shaw PE, Mischak H, Eychene A, Kolch W
A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation
Mol Cell Biol. 2003, 23(6): 1983-1993
Goerke A, Sakai N, Gutjahr E, Schlapkohl WA, Mushinski JF, Haller H, Kolch W, Saito N, Mischak H
Induction of apoptosis by protein kinase C delta is independent of its kinase activity
J Biol Chem. 2002, 277(35): 32054-32062
Dhillon AS, Pollock C, Steen H, Shaw PE, Mischak H, Kolch W
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
Mol Cell Biol. 2002, 22(10): 3237-3246
Brandt D, Gimona M, Hillmann M, Haller H, Mischak H
Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway
J Biol Chem. 2002, 277(23): 20903-20910
Walter R, Mischak H, Haller H
Haemodialysis, atherosclerosis and inflammation-identifying molecular mechanisms of chronic vascular disease in ESDR patients
Nephrol Dial Transplant. 2002, 17(Suppl 3): 24-29
Hennige AM, Fritsche A, Strack V, Weigert C, Mischak H, Borboni P, Renn W, Haring HU, Kellerer M
PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38
Biochem Biophys Res Commun. 2002, 290(1): 85-90
Krasel C, Dammeier S, Winstel R, Brockmann J, Mischak H, Lohse MJ
Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin
J Biol Chem. 2001, 276(3): 1911-1915
Janosch P, Kieser A, Eulitz M, Lovric J, Sauer G, Reichert M, Gounari F, Buscher D, Baccarini M, Mischak H, Kolch W
The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments
FASEB J. 2000, 14(13): 2008-2021
Dammeier S, Lovric J, Eulitz M, Kolch W, Mushinski JF, Mischak H
Identification of the smooth muscle-specific protein, sm22, as a novel protein kinase C substrate using two-dimensional gel electrophoresis and mass spectrometry
Electrophoresis 2000, 21(12): 2443-2453
Mai S, Hanley-Hyde J, Rainey GJ, Kuschak TI, Paul JT, Littlewood TD, Mischak H, Stevens LM, Henderson DW, Mushinski JF
Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression
Neoplasia 1999, 1(3): 241-252
Baumann M, Gires O, Kolch W, Mischak H, Zeidler R, Pich D, Hammerschmidt W
The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1
Eur J Biochem. 2000, 267(12): 3891-3901
Abraham D, Podar K, Pacher M, Kubicek M, Welzel N, Hemmings BA, Dilworth SM, Mischak H, Kolch W, Baccarini M
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation
J Biol Chem. 2000, 275(29): 22300-22304
Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM, Kolch W
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein
Mol Cell Biol. 2000, 20(9): 3079-3085
Hacker H, Mischak H, Hacker G, Eser S, Prenzel N, Ullrich A, Wagner H
Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells
EMBO J. 1999, 18(24): 6973-6982
Cooper DR, Watson JE, Patel N, Illingworth P, Acevedo-Duncan M, Goodnight J, Chalfant CE, Mischak H
Ectopic expression of protein kinase CbetaII, -delta, and -epsilon, but not -betaI or -zeta, provide for insulin stimulation of glucose uptake in NIH-3T3 cells
Arch Biochem Biophys. 1999, 372(1): 178
Caloca MJ, Garcia-Bermejo ML, Blumberg PM, Lewin NE, Kremmer E, Mischak H, Wang S, Nacro K, Bienfait B, Marquez VE, Kazanietz MG
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain
Proc Natl Acad Sci USA 1999, 96(21): 11854-11859
Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM, Kolch W
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Nature 1999, 401(6749): 173-177
Hacker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, Heeg K, Lipford GB, Wagner H
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
EMBO J. 1998, 17(21): 6230-6240
Baumann M, Mischak H, Dammeier S, Kolch W, Gires O, Pich D, Zeidler R, Delecluse HJ, Hammerschmidt W
Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation
J Virol. 1998, 72(10): 8105-8114
Lovric J, Dammeier S, Kieser A, Mischak H, Kolch W
Activated raf induces the hyperphosphorylation of stathmin and the reorganization of the microtubule network
J Biol Chem. 1998, 273(35): 22848-22855
Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Haring HU
Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)
Diabetologia. 1998, 41(7): 833-838
Wooten MW, Seibenhener ML, Heikkila JE, Mischak H
Delta-protein kinase C phosphorylation parallels inhibition of nerve growth factor-induced differentiation independent of changes in Trk A and MAP kinase signalling in PC12 cells
Cell Signal. 1998, 10(4): 265-276
Maucher C, Weissinger EM, Kremmer E, Baccarini M, Procyk K, Henderson DW, Wolff L, Kolch W, Kaspers B, Mushinski JF, Mischak H
Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines
FEBS Lett. 1998, 427(1): 29-35
Prouty SM, Maroo A, Maucher C, Mischak H, Kolch W, Sedivy JM
Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts
Biochim Biophys Acta. 1998, 1402(1): 6-16
Muller G, Storz P, Bourteele S, Doppler H, Pfizenmaier K, Mischak H, Philipp A, Kaiser C, Kolch W
Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling
EMBO J. 1998, 17(3): 732-742
Wang QJ, Acs P, Goodnight J, Blumberg PM, Mischak H, Mushinski JF
The catalytic domain of PKC-epsilon, in reciprocal PKC-delta and -epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation
Oncogene 1998, 16(1): 53-60
Ueffing M, Lovric J, Philipp A, Mischak H, Kolch W
Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity
Oncogene 1997, 15(24): 2921-2927
Kellerer M, Mushack J, Mischak H, Haring HU
Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells
FEBS Lett. 1997, 418(1-2): 119-122
Bossenmaier B, Mosthaf L, Mischak H, Ullrich A, Häring HU
Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor
Diabetologia 1997, 40(7): 863-866
Weissinger EM, Eissner G, Grammer C, Fackler S, Haefner B, Yoon LS, Lu KS, Bazarov A, Sedivy JM, Mischak H, Kolch W
Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells
Mol Cell Biol. 1997, 17(6): 3229-3241
Wang QJ, Acs P, Goodnight J, Giese T, Blumberg PM, Mischak H, Mushinski JF
The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon chimeras mediates phorbol ester-induced macrophage differentiation of mouse promyelocytes
J Biol Chem. 1997, 272(1): 76-82
Mischak H, Seitz T, Janosch P, Eulitz M, Steen H, Schellerer M, Philipp A, Kolch W
Negative regulation of Raf-1 by phosphorylation of serine 621
Mol Cell Biol. 1996, 16(10): 5409-5418
Kolch W, Philipp A, Mischak H, Dutil EM, Mullen TM, Feramisco JR, Meinkoth JL, Rose DW
Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding
Oncogene 1996, 13(6): 1305-1314
Kieser A, Seitz T, Adler HS, Coffer P, Kremmer E, Crespo P, Gutkind JS, Henderson DW, Mushinski JF, Kolch W, Mischak H
Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells
Genes Dev. 1996, 10(12): 1455-1466
Janosch P, Schellerer M, Seitz T, Reim P, Eulitz M, Brielmeier M, Kolch W, Sedivy JM, Mischak H
Characterization of IkappaB kinases IkappaB-alpha is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate
J Biol Chem. 1996, 271(23): 13868-13874
Perletti GP, Folini M, Lin HC, Mischak H, Piccinini F, Tashjian AH Jr
Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells
Oncogene 1996, 12(4): 847-854
Morawetz R, Lendenfeld T, Mischak H, Muhlbauer M, Gruber F, Goodnight J, de Graaff LH, Visser J, Mushinski JF, Kubicek CP
Cloning and characterisation of genes (pkc1 and pkcA) encoding protein kinase C homologues from Trichoderma reesei and Aspergillus niger
Mol Gen Genet. 1996, 250(1): 17-28
Kieser A, Goodnight J, Kolch W, Mischak H, Mushinski JF
Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes
FEBS Lett. 1995, 372(2-3): 189-193
Crespo P, Mischak H, Gutkind JS
Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells
Biochem Biophys Res Commun. 1995, 213(1): 266-272
Chalfant CE, Mischak H, Watson JE, Winkler BC, Goodnight J, Farese RV, Cooper DR
Regulation of alternative splicing of protein kinase C beta by insulin
J Biol Chem. 1995, 270(22): 13326-13332
Avignon A, Standaert ML, Yamada K, Mischak H, Spencer B, Farese RV
Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle
Biochem J. 1995, 308 ( Pt 1): 181-187
Goodnight JA, Mischak H, Kolch W, Mushinski JF
Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes
J Biol Chem. 1995, 270(17): 9991-10001
Li S, Janosch P, Tanji M, Rosenfeld GC, Waymire JC, Mischak H, Kolch W, Sedivy JM
Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins
EMBO J. 1995, 14(4): 685-696
Goodnight J, Mischak H, Mushinski JF
Association of elevated levels of protein kinase C-zeta mRNA and protein with murine B-lymphocytic neoplasia
Mol Carcinog. 1994, 11(3): 131-137
Eissner G, Kolch W, Mischak H, Bornkamm GW, Holler E
Differential role of protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro
Scand J Immunol. 1994, 40(4): 395-402
Hafner S, Adler HS, Mischak H, Janosch P, Heidecker G, Wolfman A, Pippig S, Lohse M, Ueffing M, Kolch W
Mechanism of inhibition of Raf-1 by protein kinase A
Mol Cell Biol. 1994, 14(10): 6696-6703
Morawetz R, Mischak H, Goodnight J, Lendenfeld T, Mushinsky JF, Kubicek CP
A protein kinase-encoding gene, pkt1, from Trichoderma reesei, homologous to the yeast YPK1 and YPK2 (YKR2) genes
Gene 1994, 146(2): 309-310
Yamada K, Standaert ML, Yu B, Mischak H, Cooper DR, Farese RV
Insulin-like effects of sodium orthovanadate on diacylglycerol-protein kinase C signaling in BC3H-1 myocytes
Arch Biochem Biophys. 1994, 312(1): 167-172
Farese RV, Standaert ML, Arnold TP, Yamada K, Musunuru K, Hernandez H, Mischak H, Cooper DR
Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes
J Clin Invest. 1994, 93(5): 1894-1899
Kazanietz MG, Bustelo XR, Barbacid M, Kolch W, Mischak H, Wong G, Pettit GR, Bruns JD, Blumberg PM
Zinc finger domains and phorbol ester pharmacophore Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products
J Biol Chem. 1994, 269(15): 11590-11594
Lehel C, Olah Z, Mischak H, Mushinski JF, Anderson WB
Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake
J Biol Chem. 1994, 269(7): 4761-4766
Li W, Mischak H, Yu JC, Wang LM, Mushinski JF, Heidaran MA, Pierce JH
Tyrosine phosphorylation of protein kinase C-delta in response to its activation
J Biol Chem. 1994, 269(4): 2349-2352
Weissinger EM, Henderson DW, Mischak H, Goodnight J, Mushinski JF
Induction of plasmacytomas that secrete monoclonal anti-peptide antibodies by retroviral transformation
J Immunol Methods 1994, 168(1): 123-130
Huppi K, Siwarski D, Goodnight J, Mischak H
Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14
Genomics 1994, 19(1): 161-162
Goodnight J, Mischak H, Mushinski JF
Selective involvement of protein kinase C isozymes in differentiation and neoplastic transformation
Adv Cancer Res. 1994, 64: 159-209
Arnold TP, Standaert ML, Hernandez H, Watson J, Mischak H, Kazanietz MG, Zhao L, Cooper DR, Farese RV
Effects of insulin and phorbol esters on MARCKS (myristoylated alanine-rich C-kinase substrate) phosphorylation (and other parameters of protein kinase C activation) in rat adipocytes, rat soleus muscle and BC3H-1 myocytes
Biochem J. 1993, 295(Pt1): 155-164
Mischak H, Pierce JH, Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF
Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta
J Biol Chem. 1993, 268(27): 20110-20115
Kazanietz MG, Areces LB, Bahador A, Mischak H, Goodnight J, Mushinski JF, Blumberg PM
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
Mol Pharmacol. 1993, 44(2): 298-307
Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, Rapp UR
Protein kinase C alpha activates RAF-1 by direct phosphorylation
Nature 1993, 364(6434): 249-252
Mischak H, Goodnight J, Henderson DW, Osada S, Ohno S, Mushinski JF
Unique expression pattern of protein kinase C-theta: high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms
FEBS Lett. 1993, 326(1-3): 51-55
Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976
J Biol Chem. 1993, 268(13): 9194-9197
Weissinger EM, Mischak H, Goodnight J, Davidson WF, Mushinski JF
Addition of constitutive c-myc expression to Abelson murine leukemia virus changes the phenotype of the cells transformed by the virus from pre-B-cell lymphomas to plasmacytomas
Mol Cell Biol. 1993, 13(4): 2578-2585
Mischak H, Goodnight JA, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz MG, Blumberg PM, Pierce JH, Mushinski JF
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
J Biol Chem. 1993, 268(9): 6090-6096
Ozawa K, Szallasi Z, Kazanietz MG, Blumberg PM, Mischak H, Mushinski JF, Beaven MA
Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells
J Biol Chem. 1993, 268(3): 1749-1756
Goodnight J, Kazanietz MG, Blumberg PM, Mushinski JF, Mischak H
The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta
Gene. 1992, 122(2): 305-311
Dlugosz AA, Mischak H, Mushinski JF, Yuspa SH
Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells
Mol Carcinog 1992, 5(4): 286-292
Mischak H, Kolch W, Goodnight J, Davidson WF, Rapp U, Rose-John S, Mushinski JF
Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific
J Immunol. 1991, 147(11): 3981-3987
Weissinger EM, Mischak H, Largaespada DA, Kaehler DA, Mitchell T, Smith-Gill SJ, Risser R, Mushinski JF
Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc
Proc Natl Acad Sci USA 1991, 88(19): 8735-8739
Mischak H, Bodenteich A, Kolch W, Goodnight J, Hofer F, Mushinski JF
Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein
Biochemistry 1991, 30(32): 7925-7931
Mischak H, Kolch W, Hofer F, Weissinger E, Gessl A, Davidson WF, Aiello FB, Blaas D, Rapp UR
A raf/myc virus immortalized macrophage cell line which supports the growth of B-cell and B-cell hybridomas
Oncogene 1990, 5(9): 1377-1382
Kolch W, Weissinger E, Mischak H, Troppmair J, Showalter SD, Lloyd P, Heidecker G, Rapp UR
Probing structure and function of the raf protein kinase domain with monoclonal antibodies
Oncogene 1990, 5(5): 713-720
Largaespada D, Kaehler D, Weissinger E, Mischak H, Mushinski F, Risser R
The activity of an ABL-MYC retrovirus in fibroblast cell lines and in lymphocytes
Curr Top Microbiol Immunol. 1990, 166: 91-96
Weissinger EM, Largaespada D, Smith-Gill SJ, Risser R, Mushinski JF, Mischak H
A retrovirus expressing v-abl and c-myc induces plasmacytomas in 100% of adult pristane-primed BALB/c mice
Curr Top Microbiol Immunol. 1990, 166: 121-127
Mischak H, Hofer F, Messner R, Weissinger E, Hayn M, Tomme P, Esterbauer H, Kuchler E, Claeyssens M, Kubicek CP
Monoclonal antibodies against different domains of cellobiohydrolase I and II from Trichoderma reesei
Biochim Biophys Acta 1989, 990(1): 1-7
Mischak H, Neubauer C, Berger B, Kuechler E, Blaas D
Detection of the human rhinovirus minor group receptor on renaturing Western blots
J Gen Virol. 1988, 69 (Pt10): 2653-2656
Mischak H, Neubauer C, Kuechler E, Blaas D
Characteristics of the minor group receptor of human rhinoviruses
Virology 1988, 163(1): 19-25
Kowalski H, Maurer-Fogy I, Zorn M, Mischak H, Kuechler E, Blaas D
Cleavage site between VP1 and P2A of human rhinovirus is different in serotypes 2 and 14
J Gen Virol. 1987, 68(Pt12): 3197-3200