| X | Definition of study cohorts: A clinical proteomic study should begin with a well-framed clinical question or problem, followed by selection of the appropriate study populations [CASE (red) vs. CONTROL (green)] and samples to be analysed. Hereby, we focused on urine, since urine is easily accessible, available in large quantities and long-term stable during storage at -20°C, yielding comparable datasets. Furthermore, urinary polypeptides display the “status” of the kidney, bladder, prostate and vascular architecture and are capable to depict systemic diseases. Other specimens, such as cerebrospinal fluid and tissue culture supernatant are suitable for analysis, as well. |  |
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